Florian Renner

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The paracaspase MALT1 plays an important role in immune receptor-driven signaling pathways leading to NF-κB activation. MALT1 promotes signaling by acting as a scaffold, recruiting downstream signaling proteins, as well as by proteolytic cleavage of multiple substrates. However, the relative contributions of these two different activities to T and B cell(More)
Antigen receptor signalling activates the canonical NF-κB pathway via the CARD11/BCL10/MALT1 (CBM) signalosome involving key, yet ill-defined roles for linear ubiquitination. The paracaspase MALT1 cleaves and removes negative checkpoint proteins, amplifying lymphocyte responses in NF-κB activation and in B-cell lymphoma subtypes. To identify new human MALT1(More)
Dhavalkumar D. Patel and Thomas Calzascia Catherine H. Régnier, Tak W. Mak, Pamela S. Ohashi, Natasa Zamurovic, Kathy D. McCoy, Antonius Rolink, Traggiai, Dirk Brenner, Anne Brüstle, Michael St. Paul, Weckbecker, Gerhard Zenke, Bernd Kinzel, Elisabetta Katopodis, Barbara Nuesslein-Hildesheim, Gisbert Christoph Burkhart, Janet Dawson, Satoru Niwa, Andreas(More)
The paracaspase MALT1 has arginine-directed proteolytic activity triggered by engagement of immune receptors. Recruitment of MALT1 into activation complexes is required for MALT1 proteolytic function. Here, co-expression of MALT1 in HEK293 cells, either with activated CARD11 and BCL10 or with TRAF6, was used to explore the mechanism of MALT1 activation at(More)
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