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Long-term potentiation (LTP) and long-term depression (LTD) underlie most models of learning and memory, but neural activity would grow or shrink in an uncontrolled manner, if not guarded by stabilizing mechanisms. The Bienenstock-Cooper-Munro (BCM) rule proposes a sliding threshold for LTP/LTD induction: LTP induction becomes more difficult if neural(More)
Cells contain many subcellular structures in which specialized proteins locally cluster. Binding interactions within such clusters may be analyzed in live cells using models for fluorescence recovery after photobleaching (FRAP). Here we analyze a three-dimensional FRAP model that accounts for a single spatially localized cluster of binding sites in the(More)
Effects of cerebellar lesions on the production of isometric pinch force and the coordination of pinch and lift force were examined. Twenty-one patients, mostly with degenerative cerebellar disorders, and ten healthy controls lifted an instrumented test object using the precision grip of thumb and index finger. The load of the object could be varied to(More)
Coincident hand and foot movements are more reliably performed in the same direction than in opposite directions. Using transcranial magnetic stimulation (TMS) to assess motor cortex function, we examined the physiological basis of these movements across three novel experiments. Experiment 1 demonstrated that upper limb corticomotor excitability changed in(More)
A precision grip task was used to test two patients with acute unilateral cerebellar lesions due to a stroke and to compare performance of the affected and the unaffected hand. The results show, that grip force development is slowed and coordination of grip and lift force impaired by the lesion. Changes in shape and peak levels of grip force rate indicate a(More)
BACKGROUND Trans-translation releases stalled ribosomes from truncated mRNAs and tags defective proteins for proteolytic degradation using transfer-messenger RNA (tmRNA). This small stable RNA represents a hybrid of tRNA- and mRNA-like domains connected by a variable number of pseudoknots. Comparative sequence analysis of tmRNAs found in bacteria, plastids,(More)
High oral perception is thought to contribute to poor adaptation to new dentures. The aim of this study was to evaluate the oral stereognosis and tactile sensibility in edentate subjects and relate these to patient age and capability of adaptation to new prostheses. A total of 67 patients were provided with new complete dentures 2-3 weeks before the(More)
A review on pollen epigenetics. Plants grow in an ever-changing environment and are used to environmental fluctuations such as high and low temperatures during their life cycles. To cope with adverse conditions, plants have evolved intricate short-term and long-term mechanisms to respond and adapt to external stresses. The plant’s ability to respond to(More)