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Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer
Analysis of adaptive kinome activity reveals paths of drug resistance in HER2-positive breast cancer. Blocking drug resistance The identification of “cancer drivers” enables the development ofExpand
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Novel human renal proximal tubular cell line for the production of complex proteins.
Human host cell lines for the production of biopharmaceutical proteins are of interest due to differences in the glycosylation patterns of human and animal cell lines. Specifically, sialylation,Expand
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Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.
MET, the product of the c-MET proto-oncogene, and its ligand hepatocyte growth factor/scatter factor (HGF/SF) control survival, proliferation and migration during development and tissue regeneration.Expand
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Optimization of a quantitative PCR based method for plasmid copy number determination in human cell lines.
Transient gene expression (TGE) is an essential tool for the production of recombinant proteins, especially in early drug discovery and development phases of biopharmaceuticals. The need for fastExpand
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High-Throughput Quantification of Surface Protein Internalization and Degradation.
Cell surface proteins are key regulators of fundamental cellular processes and, therefore, often at the root of human diseases. Thus, a large number of targeted drugs which are approved or underExpand
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Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.
Abstract MET, the product of the c-MET proto-oncogene, and its ligand hepatocyte growth factor/scatter factor (HGF/SF) control survival, proliferation and migration during development and tissueExpand
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Inhibition of the Cell Growth in M Cells by Bi-Para
MET, the product of the c-MET proto-oncogene, and its ligand hepatocyte growth factor/scatter factor (HGF/SF) control survival, proliferation andmigration during development and tissue regeneration.Expand