Florian Gruber

Learn More
OBJECTIVE Endothelial cells comprise a key component of the inflammatory response. We set out to obtain a comprehensive overview of the immediate-early to early gene expression program of interleukin-1 (IL-1)-stimulated endothelial cells and to identify novel transcription factors and regulatory elements. METHODS AND RESULTS Human umbilical vein(More)
  • Matthias Schäfer, Ann-Helen Willrodt, Svitlana Kurinna, Andrea S Link, Hany Farwanah, Alexandra Geusau +12 others
  • 2014
The transcription factor Nrf2 is a key regulator of the cellular stress response, and pharmacological Nrf2 activation is a promising strategy for skin protection and cancer prevention. We show here that prolonged Nrf2 activation in keratinocytes causes sebaceous gland enlargement and seborrhea in mice due to upregulation of the growth factor epigen, which(More)
Hyperspectral inspection using imaging systems is becoming more and more important for quality control tasks in several industries, replacing well trained operators or established machine vision systems based on RGB-systems. Hyperspectral imaging (HSI) on thin coated substrates is challenging due to the high reflectivity of the substrates. Nevertheless, the(More)
  • Rossella Monteforte, Georg F. Beilhack, Reinhard Grausenburger, Benjamin Mayerhofer, Reginald Bittner, Regina Grillari‐Voglauer +5 others
  • 2016
Senescent cells accumulate during ageing in various tissues and contribute to organismal ageing. However, factors that are involved in the induction of senescence in vivo are still not well understood. SNEV(P) (rp19/) (PSO) (4) is a multifaceted protein, known to be involved in DNA damage repair and senescence, albeit only in vitro. In this study, we used(More)
We previously showed that, when peripheral blood mononuclear cells (PBMCs) were stressed with ionizing radiation, they released paracrine factors that showed regenerative capacity in vitro and in vivo. This study aimed to characterize the secretome of PBMCs and to investigate its biologically active components in vitro and vivo. Bioinformatics analysis(More)
Oxidative stress within tissues and organs results from a failure to detoxify reactive oxygen species (ROS) and leads to damage of cellular components including proteins, DNA and lipids. This damage is thought to be a key mechanism of aging as well as to be involved in the pathogenesis of so diverse diseases as diabetes, schizophrenia, arteriosclerosis and(More)
  • 1