Florian Garo

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The most accepted animal model for simulation of the physiological and morphological consequences of microgravity on the cardiovascular system is one of head-down hindlimb unloading. Experimental conditions surrounding this model include not only head-down tilting of rats, but also social and restraint stresses that have their own influences on(More)
Oligopyrenotides, abiotic oligomers that exhibit significant structural analogies to the nucleic acids, are described. They are composed of achiral, phosphodiester-linked pyrene building blocks and a single chiral 1,2-diaminocyclohexane unit. These oligomers form stable hybrids in aqueous solution. Hybridization is based on stacking interactions of the(More)
The effect of a GC base pair on the excitation energy transfer in a DNA-based, light harvesting assembly of phenanthrene and pyrene chromophores is described. After absorption of light at 320 nm by the stacked phenanthrene building blocks, the excitation energy is transferred to the pyrene and leads to the formation of a phenanthrene-pyrene exciplex. The(More)
Eu(III) complexes of DNA containing a non-nucleosidic linker, a derivative of 1,10-phenanthroline-2,6-dicarboxamide (Q), are studied with the goal of forming novel lanthanide ion binding sites that are incorporated in the backbone of DNA. One oligonucleotide is short and unstructured (TTTQTTT (QT6)) and the other (5'-AGCTCGGTCAQCGAGAGTGCA-3' (SQ)) is(More)
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