Comparing local neural structures across large sets of examples is crucial when studying gene functions, and their effect in the Drosophila brain. The current practice of aligning brain volume data to a joint reference frame is based on the neuropil. However, even after alignment neurons exhibit residual location and shape variability that, together with… (More)
14 A central aim, from basic neuroscience to psychiatry, is to resolve how genes control 15 brain circuitry and behavior. This is experimentally hard, since most brain functions 16 and behaviors are controlled by multiple genes. In low throughput, one gene at a time, 17 experiments, it is therefore difficult to delineate the neural circuitry through which… (More)
Measuring the impact of combinations of genetic or chemical perturbations on cellular fitness, sometimes referred to as synthetic lethal screening, is a powerful method for obtaining novel insights into gene function and drug action. Especially when performed at large scales, gene-gene or gene-drug interaction screens can reveal complex genetic interactions… (More)
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