Florian Fuchs

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SUMMARY EBImage provides general purpose functionality for reading, writing, processing and analysis of images. Furthermore, in the context of microscopy-based cellular assays, EBImage offers tools to segment cells and extract quantitative cellular descriptors. This allows the automation of such tasks using the R programming language and use of existing(More)
We determined the physical locations of the heterodimeric Ecdysone receptor/Ultraspiracle (ECR/USP) nuclear hormone receptor complex throughout the entire nonrepetitive genome of Drosophila melanogaster using a cell line (Kc167) that differentiates in response to 20-hydroxyecdysone (20-HE). 20-HE, the natural ligand of this complex, controls major aspects(More)
Current cancer chemotherapies are limited by the lack of tumor-specific targets, which would allow for selective eradication of malignant cells without affecting healthy tissues. In contrast to normal cells, most tumor cells contain multiple centrosomes, which tend to cause the formation of multipolar mitotic spindles, chromosome segregation defects, and(More)
Being increasingly equipped with highly-accurate positioning technologies, today's mobile phones enable their owners to transmit their current position over the cellular network and share it with others. So-called location-based community services make use of this possibility, for example for locating friends or family members. Such services give target(More)
A systematic characterization of genes with unknown function is a key challenge after the sequencing of the human genome and the genomes of many model organisms. High-throughput RNA-interference (RNAi) screenings have become a widely used approach in invertebrate model organisms and also promise to revolutionize cell biology in mammals. Genome-wide RNAi(More)
Genetic screens for phenotypic similarity have made key contributions to associating genes with biological processes. With RNA interference (RNAi), highly parallel phenotyping of loss-of-function effects in cells has become feasible. One of the current challenges however is the computational categorization of visual phenotypes and the prediction of(More)
In order to enable a common understanding of context information we introduce a modeling concept that embraces four abstraction layers from meta-metamodel and metamodel to model and instance layer. Being compliant to OWL DL we especially consider the ability of reasoning over the information and the modeling of quality attributes.
Service-orientation enables dynamic interoperation of distributed services and facilitates seamless service provision or runtime creation of new applications. This dynamic service composition is particularly powerful in peer-to-peer (P2P) systems which offer scalability through self-management and autonomy. However, P2P service composition is nontrivial due(More)
BACKGROUND In Drosophila, the early secretory apparatus comprises discrete paired Golgi stacks in close proximity to exit sites from the endoplasmic reticulum (tER sites), thus forming tER-Golgi units. Although many components involved in secretion have been identified, the structural components sustaining its organisation are less known. Here we set out to(More)
Being increasingly equipped with highly-accurate positioning technologies, today’s mobile phones enable their owners to transmit their current position over the cellular network and share it with others. So-called location-based community services make use of this possibility, for example for locating friends, co-workers or family members. Of course, these(More)