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Recent advances have led to insights into the structure of the bacterial ribosome, but little is known about the 3D organization of ribosomes in the context of translating polysomes. We employed cryoelectron tomography and a template-matching approach to map 70S ribosomes in vitrified bacterial translation extracts and in lysates of active E. coli(More)
The use of cues to voicing perception of initial stop consonants in multiple spoken syllables was studied for moderately/severely hearing-impaired (n = 43) and normal-hearing listeners (n = 12). The test stimuli were ten utterances each of the syllables/baed, gaed, daed, paed, kaed, taed/. The utterances were analyzed acoustically to confirm the presence of(More)
Ribosomes arranged in pairs (100S) have been related with nutritional stress response and are believed to represent a "hibernation state." Several proteins have been identified that are associated with 100S ribosomes but their spatial organization has hitherto not been characterized. We have used cryoelectron tomography to reveal the three-dimensional(More)
Hearing-impaired persons with reduced voicing perception for final fricatives were studied for improvement in perception via training or enhancement of the vowel duration cue. Ten utterances each of the syllables /baef, baes, baev, baez/ composed three stimulus sets that were graded for the magnitude of the vowel duration cue. These sets were used(More)
A further study is reported from a program of research exploring the improvement of speech perception by hearing-impaired persons via enhancement of acoustic features of consonants (10,11). Enhancements were applied to certain acoustic segments of consonants, segments known to be useful in consonant perception by normal-hearing persons but often not for(More)
Diese Dissertation wurde selbständig, ohne unerlaubte Hilfen erarbeitet. Acknowledgements I would like to thank Prof. F. Ulrich Hartl for providing me the opportunity to work under his guidance and introducing me to the fascinating field of Chaperone mediated protein folding. His constant support, encouragement, ideas and often stimulating discussions were(More)
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