Florian Bossard

Learn More
In cystic fibrosis (CF), the DeltaF508-CFTR anterograde trafficking from the endoplasmic reticulum to the plasma membrane is inefficient. New strategies for increasing the delivery of DeltaF508-CFTR to the apical membranes are thus pathophysiologically relevant targets to study for CF treatment. Recent studies have demonstrated that PDZ-containing proteins(More)
The cystic fibrosis transmembrane conductance regulator (CFTR) represents the main Cl channel in the apical membrane of epithelial cells for cAMP-dependent Cl secretion. Here we report on the synthesis and screening of a small library of nontoxic -aminoazaheterocycle-methylglyoxal adducts, inhibitors of wild-type (WT) CFTR and G551D-, G1349D-, and(More)
Florian Bossard,* Amal Robay,* Gilles Toumaniantz, Shehrazade Dahimene, Frédéric Becq, Jean Merot, and Chantal Gauthier Institut National de la Santé et de la Recherche Médicale Unité 533, l’ Institut du Thorax, Faculté de Médecine, Nantes; Centre National de la Recherche Scientifique Unité Mixte de Recherches 6187, Institut de Physiologie et Biologie(More)
The cystic fibrosis transmembrane conductance regulator (CFTR) represents the main Cl(-) channel in the apical membrane of epithelial cells for cAMP-dependent Cl(-) secretion. Here we report on the synthesis and screening of a small library of nontoxic alpha-aminoazaheterocycle-methylglyoxal adducts, inhibitors of wild-type (WT) CFTR and G551D-, G1349D-,(More)
To date, three β-adrenoceptor (β-AR) subtypes have been identified, but only β(1)-ARs and β(2)-ARs have been characterized in human lungs. Moreover, β(2)-ARs physically interact with the cystic fibrosis transmembrane conductance regulator (CFTR) through the Na(+)/H(+) Exchanger Regulatory Factor 1 (NHERF1) protein. β(3)-ARs, which stimulate CFTR activity in(More)
  • 1