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Variation in susceptibility to infectious disease often has a substantial genetic component in animal and plant populations. We have used genome-wide association studies (GWAS) in Drosophila melanogaster to identify the genetic basis of variation in susceptibility to viral infection. We found that there is substantially more genetic variation in(More)
To understand the molecular basis of how hosts evolve resistance to their parasites, we have investigated the genes that cause variation in the susceptibility of Drosophila melanogaster to viral infection. Using a host-specific pathogen of D. melanogaster called the sigma virus (Rhabdoviridae), we mapped a major-effect polymorphism to a region containing(More)
BACKGROUND Incidence rates of renal replacement therapy (RRT) for end-stage renal disease (ESRD) vary geographically not only between but within countries. This study uses data from the French REIN registry to quantify the extent to which socio-economic environment, health care supply and medical practice patterns such as early dialysis initiation or(More)
The relative age of an individual's siblings is a major cause of fitness variation in many species. In Blue tits (Cyanistes caeruleus), we show that age hierarchies are predominantly caused by incubation preclutch completion, such that last laid eggs hatch later than early laid eggs. However, after statistically controlling for incubation behavior late laid(More)
Even though knowledge management has been around for more than a decade, so far concrete instruments that can be systematically deployed are still rare. This paper presents an optimization solution targeted at flexible management of office space considering knowledge management criteria in order to enhance knowledge work productivity. The paper presents the(More)
Hosts encounter an ever-changing array of pathogens, so there is continual selection for novel ways to resist infection. A powerful way to understand how hosts evolve resistance is to identify the genes that cause variation in susceptibility to infection. Using high-resolution genetic mapping we have identified a naturally occurring polymorphism in a gene(More)
The authors would like to correct four errors in the manuscript: 1. In Fig 5C, the relative viral titre bars are at the wrong height. In the figure, the Ge-1(S) ctrl (grey bar) and Ge-1(H) ctrl (grey bar) have higher relative viral titre than Ge-1(S) DCP1 KD (red bar) and Ge-1(H) DCP1 KD (blue bar). However, the DCP1 KD should have higher viral titres than(More)