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To meet the challenge of developing a comprehensive weather and climate prediction model which can give realistic scenarios for many time scales, more computer power than is currently available will be needed. One possibility for alleviating this shortcoming is to increase the integration timestep. We propose and test several methods which may prove useful.(More)
OBJECTIVE Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is associated with an enhanced risk for liver and cardiovascular diseases and mortality. NAFLD can progress from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH). However, the mechanisms predisposing to this progression remain undefined. Notably,(More)
Today, in more and more enterprises digital services are offered to employees. An inherent characteristic of digital service is the self-service concept. Based on findings from a case study and academic literature, it is argued for the importance of employee knowledge when designing digital services. It is revealed that existing service blueprinting(More)
Enteroendocrine cells (EEC) produce neuropeptides, which are crucially involved in the maintenance of the intestinal barrier. Hence, EEC dysfunction is suggested to be involved in the complex pathophysiology of inflammatory bowel disease (IBD), which is characterized by decreased intestinal barrier function. However, the underlying mechanisms for EEC(More)