Florian A. Bayer

Learn More
To understand the molecular basis of how hosts evolve resistance to their parasites, we have investigated the genes that cause variation in the susceptibility of Drosophila melanogaster to viral infection. Using a host-specific pathogen of D. melanogaster called the sigma virus (Rhabdoviridae), we mapped a major-effect polymorphism to a region containing(More)
Variation in susceptibility to infectious disease often has a substantial genetic component in animal and plant populations. We have used genome-wide association studies (GWAS) in Drosophila melanogaster to identify the genetic basis of variation in susceptibility to viral infection. We found that there is substantially more genetic variation in(More)
The number of tumor-infiltrating lymphocytes is functionally important and correlates with clinical outcome in several tumor entities. Herein we explore the impact of the density of T and B lymphocytes in prostate cancer tissue on prostate-specific antigen (PSA) recurrence after prostatectomy in 3261 prostate cancer tissue samples. The number of prostate(More)
BACKGROUND Incidence rates of renal replacement therapy (RRT) for end-stage renal disease (ESRD) vary geographically not only between but within countries. This study uses data from the French REIN registry to quantify the extent to which socio-economic environment, health care supply and medical practice patterns such as early dialysis initiation or(More)
Hosts encounter an ever-changing array of pathogens, so there is continual selection for novel ways to resist infection. A powerful way to understand how hosts evolve resistance is to identify the genes that cause variation in susceptibility to infection. Using high-resolution genetic mapping we have identified a naturally occurring polymorphism in a gene(More)
UNLABELLED ♦ BACKGROUND Health-care systems must attempt to provide appropriate, high-quality, and economically sustainable care that meets the needs and choices of patients with end-stage renal disease (ESRD). France offers 9 different modalities of dialysis, each characterized by dialysis technique, the extent of professional assistance, and the(More)
BACKGROUND Variations in the timing of dialysis initiation may explain some geographical variations in renal replacement therapy (RRT) incidence, but this effect has never been quantified. METHODS Using data from the French Renal Epidemiology and Information Network registry, we quantified the association between RRT incidence in 2006-07 and median(More)
1. In Fig 5C, the relative viral titre bars are at the wrong height. In the figure, the Ge-1(S) ctrl (grey bar) and Ge-1(H) ctrl (grey bar) have higher relative viral titre than Ge-1(S) DCP1 KD (red bar) and Ge-1(H) DCP1 KD (blue bar). However, the DCP1 KD should have higher viral titres than the controls in both S and H backgrounds. This mistake was made(More)