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Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation
TLDR
Investigation of the effect of bacterial lipopolysaccharides on tumor proliferation in vitro in the non-small cell lung cancer cell line A549 revealed that the proliferative effect of LPS was dependent on CD14 and Toll-like receptor (TLR)4 and blocking of the epidermal growth factor receptor (EGFR) also decreased LPS-induced proliferation of A549 cells. Expand
Interactions between neutrophils and non-small cell lung cancer cells: enhancement of tumor proliferation and inflammatory mediator synthesis
TLDR
It is suggested that direct cell–cell interactions between neutrophils and tumor cells cause release of inflammatory mediators which, in turn, may enhance tumor growth in NSCLC. Expand
Carbon ion radiotherapy of human lung cancer attenuates HIF‐1 signaling and acts with considerably enhanced therapeutic efficiency
TLDR
The evidence showed that carbon ions mediate an improved therapeutic effectiveness without tumor‐promoting HIF‐1 signaling, and indicates a higher relative biological effectiveness (RBE) than anticipated from the cell survival data. Expand
Lipoteichoic acids from Staphylococcus aureus stimulate proliferation of human non-small-cell lung cancer cells in vitro
TLDR
LTA of S. aureus induced proliferation of NSCLC cell lines of adeno- and squamous cell carcinoma origin, indicating that pulmonary infections may exert a direct pro-proliferative effect on lung cancer growth. Expand
TLR4- and TLR9-dependent effects on cytokines, cell viability, and invasion in human bladder cancer cells.
TLDR
It is demonstrated that bladder cancer cell lines express functional TLR4 and TLR9 with possible effects on cancer progression and outcome of BCG-based immunotherapy. Expand
Roscovitine strongly enhances the effect of olaparib on radiosensitivity for HPV neg. but not for HPV pos. HNSCC cell lines
TLDR
Whether roscovitine, an inhibitor of cyclin-dependent kinases (CDKs), which hereby also blocks homologous recombination (HR), can be used to enhance the radiation sensitivity of HNSCC cell lines is tested. Expand
Dual PI3K/mTOR Inhibitor NVP-BEZ235 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Due to Suppressed Double-Strand Break (DSB) Repair by Non-Homologous End
TLDR
The data indicate that targeting the PI3K/Akt/mTOR pathway by BEZ235 with concurrent radiotherapy may be considered an effective strategy for the treatment of HNSCC, regardless of the HPV and Akt status. Expand
Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines
TLDR
It is shown that in NSCLC cells LPS leads to a CREB dependent radioresistance which is, however, reversible through CBP inhibition by the specific inhibitor ICG-001, which indicates that the combined treatment with radiation and CBB inhibition may improve survival of NSCLc patients suffering from pulmonary infections. Expand
Cancer cell motility is affected through 3D cell culturing and SCF/c-Kit pathway but not by X-irradiation.
TLDR
X-irradiation affects neither the expression of important EMT genes such as vimentin, E-cadherin and N-c cadherin nor SCF/c-Kit signaling and, as a consequence, does not alter cell motility. Expand
In cancer cell lines inhibition of SCF/c-Kit pathway leads to radiosensitization only when SCF is strongly over-expressed
TLDR
Generally, the SCF/c-Kit pathway does not have a dominant effect on both, cell survival and radioresponse and, as a consequence, knockdown of this pathwaydoes not result in a strong effect on radioresistance, except when SCF is strongly over-expressed. Expand
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