Florence Pichon

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Factor-dependent hamster lung fibroblasts (CCL39) were transfected with plasmid vectors expressing normal Ha-ras, T24 Ha-ras, V-Ki-ras or myc oncogenes placed under the transcriptional control of potent viral or inducible (metallothionein-I) promoters. The rate at which clonal isolates proliferated in monolayer cultures in serum-free medium or in response(More)
MeWo melanoma cells (clone LC1) secrete a potent mitogenic activity susceptible to reinitiate DNA replication in quiescent rodent fibroblasts (CCL39, NRK-49F, NIH-3T3) but not in BHK-21 kidney cells. This activity appears to be closely related to platelet-derived growth factor (PDGF) based on 1) its cationic nature, heat and acid resistance, but sensitivity(More)
A Ever since Ramon y Cajal's pioneering experiments in the field l 8 l, it has been generally accepted that in higher mammals, nerve fibers in the Central Nervous System cannot regenerate after complete section Such is, however, not the case for fibers in the Peripheral Nervous System. Among the various factors held responsible for this, we have singled out(More)
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