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Identifying the mechanisms of eukaryotic genome evolution by comparative genomics is often complicated by the multiplicity of events that have taken place throughout the history of individual lineages, leaving only distorted and superimposed traces in the genome of each living organism. The hemiascomycete yeasts, with their compact genomes, similar(More)
We have screened the genome of Saccharomyces cerevisiae for fragments that confer a growth-retardation phenotype when overexpressed in a multicopy plasmid with a tetracycline-regulatable (Tet-off) promoter. We selected 714 such fragments with a mean size of 700 base-pairs out of around 84,000 clones tested. These include 493 in-frame open reading frame(More)
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Large-scale exploration of growth inhibition caused by overexpression of genomic fragments in Saccharomyces cerevisiae <p>We have screened the genome of <it>Saccharomyces cerevisiae </it>for fragments that confer a growth-retardation(More)
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