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Nox1-dependent superoxide production controls colon adenocarcinoma cell migration.
TLDR
It is concluded that Nox1 activation by arachidonic acid metabolism occurs through 12-lipoxygenase and protein kinase C delta, and controls cell migration by affecting integrin alpha 2 subunit turn-over. Expand
Biodistribution and pharmacokinetics of EGFR-targeted thiolated gelatin nanoparticles following systemic administration in pancreatic tumor-bearing mice.
TLDR
EGFR-targeted and PEG-modified nanoparticles were suitable vehicles for specific systemic delivery in subcutaneous Panc-1 tumor xenograft models and displayed almost twice tumor targeting efficiency, highlighting the efficacy of the active targeting strategy. Expand
Nox1 downstream of 12‐lipoxygenase controls cell proliferation but not cell spreading of colon cancer cells
TLDR
The results suggest that the 12‐lipoxygenase pathway is upstream of Nox1 activation and controls cell spreading and proliferation, while Nox 1 specifically affects cell proliferation. Expand
Biodistribution and pharmacokinetics of Mad2 siRNA-loaded EGFR-targeted chitosan nanoparticles in cisplatin sensitive and resistant lung cancer models.
BACKGROUND The present study focuses on biodistribution profile and pharmacokinetic parameters of EGFR-targeted chitosan nanoparticles (TG CS nanoparticles) for siRNA/cisplatin combination therapy ofExpand
Pharmacology of EAPB0203, a novel imidazo[1,2-a]quinoxaline derivative with anti-tumoral activity on melanoma.
TLDR
In xenografted mouse, after intraperitoneal administration of 5 and 20mg/kg, EAPB0203 is more potent than fotemustine, and the survival time was increased up to 4 and 2 weeks compared to control mice and mice treated by fotamustine. Expand
Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity
TLDR
It is concluded that EAPB0203, EAPb0503, as well as imiquimod, interact with tubulin through the colchicine binding site, and that the cytotoxic activity of E APB0 203,EAPB0503 and imiquIMod is correlated to their tubulin inhibiting effect. Expand
In vivo biodistribution of siRNA and cisplatin administered using CD44-targeted hyaluronic acid nanoparticles.
TLDR
The findings demonstrate that the distribution pattern of the siRNA and cisplatin using specifically engineered CD44 targeting HA NPs correlated well with the tumor targeting capability as well as the activity and efficacy obtained with combination treatments. Expand
Additional cytotoxic pyridoacridine alkaloids from the ascidian Cystodytes violatinctus and biogenetic considerations.
TLDR
The structures of four new members of this family, shermilamine F, dehydrokuanoniamine F, and arnoamines C and D, were elucidated on the basis of NMR and MS data and by comparison with data of known compounds isolated from this genus. Expand
Comparative Biodistribution and Pharmacokinetic Analysis of Cyclosporine-A in the Brain upon Intranasal or Intravenous Administration in an Oil-in-Water Nanoemulsion Formulation.
TLDR
These studies show that IN delivery of CsA-NE is an effective way of brain targeting compared to that of other treatment strategies and significantly limits peripheral exposure and the potential for off-target toxicity. Expand
Enhanced anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles.
TLDR
Bevacizumab-loaded poly(D,L-lactic-co-glycolic acid) nanoparticles (PLGA NP) were developed and intranasally administrated in CD-1 mice to study their pharmacokinetic and pharmacodynamic profile and it is believed that this strategy would be an efficient alternative to improve GBM treatment with high impact for patient life quality and survival. Expand
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