Florence Appel

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The neural cell adhesion molecule L1 is a multidomain protein that plays important roles in cell adhesion, migration, and neurite outgrowth. To analyze structure-function relationships of L1 in neurite outgrowth and cell body adhesion, we have expressed and purified a set of different fragments of the extracellular part of this glycoprotein in CHO cells and(More)
To determine the domains of the neural cell adhesion molecule L1 involved in neurite outgrowth, we have generated monoclonal antibodies against L1 and investigated their effects on neurite outgrowth of small cerebellar neurons in culture. When the 10 antibodies were coated as substrate, only antibody 557.B6, which recognizes an epitope represented by a(More)
The neural cell adhesion molecule L1 is a multidomain protein that plays important roles in cell adhesion, migration, and neurite outgrowth. It can interact with itself by a self-binding, i.e., homophilic adhesion mechanism (Kadmon et al.: J Cell Biol 110: 193-208, 1990a). To determine the domains of L1 involved in homophilic binding, we have generated(More)
C omputer science courses that focus on the social and ethical implications of widespread computer usage have grown in popularity over the last ten to fifteen years. As more computer science educators recognize their professional obligation to prepare their students to be good theoreticians and practitioners, they are developing courses of study that(More)
1. SUMMARY The session, which is being held on the occasion of SIGCAS' 40 th Anniversary, will provide a historical perspective on curricular efforts to address the profound social and ethical impact of the rapid development of computer technology since its widespread deployment in the 1960's. Presenters, who represent veteran and newer members of SIGCAS,(More)
Transcribed from email correspondence [Q1] Looking back, what was it that first sparked your interest in computer/information ethics? [A]: It was a recognition on my part that two research areas of mine could be combined to help us understand this area. I was interested in what is now called "social nformatics" in Europe and also in how people think about(More)
Back in 1988, when my department chair encouraged me to pursue my interest in developing a course on the social and ethical impact of computing, I was thrilled at the prospect but had no idea how difficult it would be to find resources to support my teaching. I did some pre-Web digging and found two organizations that delivered on their promises to provide(More)
1. SUMMARY The session, which is being held on the occasion of SIGCAS' 40 th Anniversary, will provide a historical perspective on curricular efforts to address the profound social and ethical impact of the rapid development of computer technology since its widespread deployment in the 1960's. Presenters, who represent veteran and newer members of SIGCAS,(More)
The ACM SIGITE Curriculum Committee 2005 has recently published recommendations paying significant attention to the coverage of societal and ethical issues and professional responsibility. It is expected that a growing number of IT departments and schools will seek to address these curricular issues. This panel will examine a variety of approaches to(More)