Fleur S van de Bovenkamp

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Human IgG is the most abundant glycoprotein in serum and is crucial for protective immunity. In addition to conserved IgG Fc glycans, ∼15-25% of serum IgG contains glycans within the variable domains. These so-called "Fab glycans" are primarily highly processed complex-type biantennary N-glycans linked to N-glycosylation sites that emerge during somatic(More)
OBJECTIVE Intestinal inflammation resulting from manipulation-induced mast cell activation is a crucial mechanism in the pathophysiology of postoperative ileus (POI). Recently it has been shown that spleen tyrosine kinase (Syk) is involved in mast cell degranulation. Therefore, we have evaluated the effect of the Syk-inhibitor GSK compound 143 (GSK143) as(More)
In immune thrombocytopenia and warm autoimmune hemolytic anemia, circulating immunoglobulin G (IgG)-opsonized blood cells are cleared from the circulation by macrophages. Administration of intravenous immunoglobulin (IVIg) can prevent uptake, but the exact working mechanism is not known. The prevailing theory from murine studies, which states that(More)
Department of Blood Cell Research, Department of Experimental Immunohematology, and Department of Immunopathology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands; and Emma Children’s(More)
Fig. S1. Skewed IGH gene repertoire in fetal naive B cells. Fig. S2. IGHV, IGHD and IGHJ gene usage, IgH-CDR3 length, and N-nucleotides in DH-JH and VH-DJH junctions in out-of-frame IGH rearrangements in pre-BI cells from fetal liver, fetal BM and pediatric BM. Fig. S3. IGKV and IGKJ gene usage in single-sorted naive mature-B cells from fetal and pediatric(More)
Ann Rheum Dis Month 2017 Vol 0 No 0 Figure 1 Molecular size analysis of ACPA-IgG and -IgM. (A) Presence of anti-citrullinated protein antibody (ACPA)-IgG (black dots) and noncitrulline-specific IgG (white dots) in gel-filtration chromatography fractions (lower fraction number indicates larger size; representative example of seven donors). (B) Western blot(More)
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