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The objective of this study was to compare the efficacy of the alpha-2a agonist guanfacine with that of dextroamphetamine for the treatment of adult attention-deficit/hyperactivity disorder (ADHD). Seventeen adult outpatients who met DSM-IV criteria for ADHD participated in a double-blind, placebo-controlled, crossover study comparing drug effects on ADHD(More)
BACKGROUND Excessive brain responsiveness to norepinephrine appears to contribute to post-traumatic stress disorder (PTSD), particularly at night. Prazosin, a brain active alpha-1 adrenergic receptor antagonist, significantly reduced trauma nightmares and sleep disturbance in 10 Vietnam War combat veterans in a previous placebo-controlled crossover study.(More)
BACKGROUND Prazosin, a central nervous system (CNS) active alpha-1 adrenoreceptor antagonist, has reduced nightmares and sleep disturbance in placebo-controlled studies of combat-related posttraumatic stress disorder (PTSD). We evaluated objective sleep parameters and PTSD symptoms in a placebo-controlled prazosin trial for civilian trauma-related PTSD. (More)
Heightened noradrenergic reactivity may be a contributing factor in the pathophysiology of posttraumatic stress disorder (PTSD). Prazosin is an alpha1-adrenoceptor antagonist commonly used as an antihypertensive agent. Because alpha1-adrenergic activity has been associated with fear and startle responses, a drug that blocks central alpha1-adrenergic(More)
BACKGROUND Persons with posttraumatic stress disorder (PTSD) whose trauma-related nightmares improve or resolve with bedtime administration of the alpha-1 adrenergic antagonist prazosin often continue to experience PTSD symptoms during the day. This study addressed whether daytime prazosin compared to placebo would alleviate psychological distress provoked(More)
BACKGROUND Posttraumatic stress disorder (PTSD) is often a chronic disorder, and, though 2 antidepressants are now approved by the U.S. Food and Drug Administration for its treatment, it often remains refractory to pharmacotherapy. The memory of traumatic events, by repeatedly stimulating the hippocampus and amygdala (kindling phenomenon), may alter(More)
Research on the neurobiology of the stress response in animals has led to successful new treatments for Post-Traumatic Stress Disorder (PTSD) in humans. Basic research has found that high levels of catecholamine release during stress rapidly impair the top-down cognitive functions of the prefrontal cortex (PFC), while strengthening the emotional and(More)
SUMMARY Indium-111 ("'In) bound to 8-hydroxyquinoline can be used to label platelets without impairing their ability to participate in active thrombosis. The purpose of this study was to identify intracardiac thrombi using "'In platelet scintigraphy. Twenty-nine patients were studied. Twenty-one had discrete left ven-tricular aneurysms (group 1). The(More)
The in vitro and in vivo behaviour of platelets was studied in eleven patients with left ventricular aneurysms and mural thrombi. Five patients were on aspirin 300-2400 mg/day; the remaining six patients were controls. In vitro function was tested by the aggregation response of platelets to adenosine diphosphate (ADP) and collagen. In vivo function was(More)
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