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  • Giuseppe Faraco, Silvia Fossati, +5 authors Alberto Chiarugi
  • Biology, Medicine
  • Journal of neurochemistry
  • 2007 (First Publication: 29 June 2007)
  • High mobility group proteins are chromatin binding factors with key roles in maintenance of nuclear homeostasis. The evidence indicates that extracellularly released high mobility group box 1 (HMGB1)Expand
  • Giuseppe Faraco, Tristano Pancani, +5 authors Alberto Chiarugi
  • Medicine, Biology
  • Molecular Pharmacology
  • 2006 (First Publication: 1 December 2006)
  • Pharmacological manipulation of gene expression is considered a promising avenue to reduce postischemic brain damage. Histone deacetylases (HDACs) play a central role in epigenetic regulation ofExpand
  • Cristina Cosi, G Mannaioni, Andrea Cozzi, Vincenzo Carlá, Flavio Moroni
  • Chemistry, Medicine
  • Neuropharmacology
  • 2011 (First Publication: 1 June 2011)
  • G-protein coupled receptor 35 (GPR35) is a former "orphan receptor" expressed in brain and activated by either kynurenic acid or zaprinast. While zaprinast has been studied as a phosphodiesteraseExpand
  • Giulia Cipriani, Elena Rapizzi, Alfredo Vannacci, Rosario Rizzuto, Flavio Moroni, Alberto Chiarugi
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2005 (First Publication: 4 March 2005)
  • To obtain further information on time course and mechanisms of cell death after poly(ADP-ribose) polymerase-1 (PARP-1) hyperactivation, we used HeLa cells exposed for 1 h to the DNA alkylating agentExpand