Flavien Léger

Learn More
There have been very few population pharmacokinetic (PopPK) studies and Bayesian forecasting methods dealing with cyclosporin (CsA) so far, probably because of the difficulty of modeling the particular absorption profiles of CsA. The present study was conducted in stable renal transplant patients treated with Neoral and employed the NONMEM program. Its(More)
OBJECTIVE The aim of this study was to develop routinely applicable limited sampling strategies for assessing cyclosporin (CsA) AUC(0-12 h), and possibly other exposure indices such as AUC(0-4 h) and C(max), in heart transplant patients over the first year post-transplantation. METHODS First, the individual pharmacokinetics (PKs) of 14 adult(More)
A retrospective population pharmacokinetic (PPK) analysis was performed in 24 pediatric patients (PEDS) (0.45-16.7 years old) receiving i.v. busulfan/cyclophosphamide (i.v. Bu/Cy 4) regimen prior to allogeneic hematopoietic stem cell transplantation. I.V. Bu doses were given as a 2-hour infusion every 6 h over 4 days. Initial dosing of i.v. Bu was 1 mg/kg(More)
An IV form of busulfan (IV Bu) has recently become available for high dose conditioning regimen before haematopoietic stem cell transplantation (HSCT). This IV form is expected to reduce the high pharmacokinetic variability exhibited with oral busulfan and as a result, to better target the plasma area under the curve (AUC). Pharmacokinetics (PK) of IV Bu(More)
This paper considers the multidimensional active scalar problem of motion of a function ρ(x, t) by a velocity field obtained by v = −∇N * ρ, where N is the Newtonian potential. We prove well-posedness of compactly supported L ∞ ∩ L 1 solutions of possibly mixed sign. These solutions include an important class of solutions that are proportional to(More)
A general framework based on Gaussian models and a MAPEM algorithm is introduced in this paper for solving matrix/ table completion problems. The numerical experiments with the standard and challenging movie ratings data show that the proposed approach, based on probably one of the simplest probabilistic models, leads to the results in the same ballpark as(More)
Several studies have shown that hemorrheological parameters are modified by physical exercise and exposure to altitude hypoxia. These changes result in a decrease in red cell deformability (RCD). Similarly, it has been shown that a daily dietary fish oil supplement increases RCD. The purpose of this study was to evaluate the influence of fish oil diet on(More)
OBJECTIVE This study was conducted to retrospectively compare the area under the curve (AUC) and the total clearance of busulfan (Bu) following oral and intravenous (IV) administrations and to determine which intravenous dose generated equivalent exposure to that of the oral form that has been marketed for decades. METHODS Patient pharmacokinetics were(More)
Received (Day Month Year) Revised (Day Month Year) Communicated by (xxxxxxxxxx) This paper considers the multidimensional active scalar problem of motion of a function ρ(x, t) by a velocity field obtained by v = −∇N * ρ, where N is the Newtonian potential. We prove well-posedness of compactly supported L ∞ ∩ L 1 solutions of possibly mixed sign. These(More)
UNLABELLED Anal incontinence (AI) is a frequent symptom with considerable impact on quality of life. The aim of this study was to describe the clinical, sonographic and manometric characteristics of a male population with AI. MATERIALS AND METHODS Endoanal ultrasonography (EAU) was performed in 92 men referred for exploration of AI. Anal incontinence(More)