Flavia Vitale

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The development of microelectrodes capable of safely stimulating and recording neural activity is a critical step in the design of many prosthetic devices, brain-machine interfaces, and therapies for neurologic or nervous-system-mediated disorders. Metal electrodes are inadequate prospects for the miniaturization needed to attain neuronal-scale stimulation(More)
The chemistry that governs the dissolution of device-grade, monocrystalline silicon nanomembranes into benign end products by hydrolysis serves as the foundation for fully eco/biodegradable classes of high-performance electronics. This paper examines these processes in aqueous solutions with chemical compositions relevant to groundwater and biofluids. The(More)
A third of all epilepsy patients who experience continuous seizures are treated with surgery to remove epileptogenic brain tissue. Currently, surgeons determine resectable tissue using electrocorticography (ECoG), a technique that detects action potentials or electrical differences within neurons in the brain. Current ECoG electrodes are not flexible enough(More)
The need for novel, high performance actuators felt in several fields of robotics, such as assistive or rehabilitative robotics, is not fully satisfied by current actuation means. This fosters an intense research on novel energy transduction methods. In particular, propellant-based chemical actuators, able to directly convert chemical energy into mechanical(More)
The major limitation of current engineered myocardial patches for the repair of heart defects is that insulating polymeric scaffold walls hinder the transfer of electrical signals between cardiomyocytes. This loss in signal transduction results in arrhythmias when the scaffolds are implanted. We report that small, subtoxic concentrations of single-walled(More)
OBJECTIVE The vision of bioelectronic medicine is to treat disease by modulating the signaling of visceral nerves near various end organs. In small animal models, the nerves of interest can have small diameters and limited surgical access. New high-resolution methods for building nerve interfaces are desirable. In this study, we present a novel nerve(More)
Soft and conductive nanomaterials like carbon nanotubes, graphene, and nanowire scaffolds have expanded the family of ultraflexible microelectrodes that can bend and flex with the natural movement of the brain, reduce the inflammatory response, and improve the stability of long-term neural recordings. However, current methods to implant these highly(More)
The need for novel, high performance actuators felt in several fields of robotics, such as assistive or rehabilitative robotics, is not fully satisfied by current actuation means. This fosters an intense research on novel energy transduction methods. In particular, propellant-based chemical actuators, able to directly convert chemical energy into mechanical(More)
OBJECTIVE Implanting subdural and penetrating electrodes in the brain causes acute trauma and inflammation that affect intracranial electroencephalographic (iEEG) recordings. This behavior and its potential impact on clinical decision-making and algorithms for implanted devices have not been assessed in detail. In this study we aim to characterize the(More)
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