Fiona Shaw

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The release of peptide hormones and uptake of radiolabelled calcium were measured in isolated rat neurohypophyses incubated in vitro. Neuropeptide release was provoked either by depolarising the tissue with raised extracellular potassium, or by application of biphasic electrical stimulus pulses. Potassium stimulation increased uptake of radiolabelled(More)
Neuronal perikarya containing vasopressin mRNA were detected in cryostat sections of cynomolgus monkey brains by using an in situ hybridization technique. The neurones were observed in hypothalamic regions (supraoptic nucleus, paraventricular nucleus, suprachiasmatic nucleus and accessory supraoptic nucleus). These findings are in agreement with previous(More)
Parallel electrocorticograms (ECoG) and electroencephalograms (EEG) were recorded during stun-recovery and stun-slaughter of eight calves 4-6 weeks old. Epochs of 8·2 s duration, derived from the ECoG and EEG signals pre-stun, during recovery and during exsanguination, were compared for differences in power content and frequency distribution using Fast(More)
The physiological significance of the 'bursting' pattern of firing exhibited by activated vasopressin-secreting neurones was investigated by delivering bursts of electrical stimuli to isolated rat neurohypophyses incubated in vitro and by determining vasopressin release. The stimuli were delivered in bursts at three different average frequencies (2.5, 5.0,(More)
cAMP signaling pathways can both stimulate and inhibit the development of cancer; however, the sources of cAMP important for tumorigenesis remain poorly understood. Soluble adenylyl cyclase (sAC) is a non-canonical, evolutionarily conserved, nutrient- and pH-sensing source of cAMP. sAC has been implicated in the metastatic potential of certain cancers, and(More)
Electroencephalograms (EEGs) were recorded before and after 'head-only' electrical stunning of adult cattle. Epochs of 8·5 s duration derived from the pre-and the post-stun EEG signals were compared for differences in scale and frequency. The frequency structures of two selected epochs from the one animal were evaluated using the periodogram ordinates(More)
Synapses in the lateral septum of the murine brain have been investigated by ultrastructural immunocytochemistry, using monoclonal anti-neurophysins in both immunoperoxidase and immunogold techniques. In the region shown by light microscopy to be rich in vasopressinergic innervation, synaptic boutons containing approximately 30 nm clear vesicles and(More)