• Publications
  • Influence
N-type Ca2+ channels carry the largest current: implications for nanodomains and transmitter release
Presynaptic terminals favor intermediate-conductance CaV2.2 (N type) over high-conductance CaV1 (L type) channels for single-channel, Ca2+ nanodomain–triggered synaptic vesicle fusion. However, theExpand
  • 96
  • 10
Synaptic vesicle tethering and the CaV2.2 distal C-terminal
Evidence that synaptic vesicles (SVs) can be gated by a single voltage sensitive calcium channel (CaV2.2) predict a molecular linking mechanism or “tether” (Stanley, 1993). Recent studies haveExpand
  • 24
  • 4
Synaptic vesicle capture by CaV2.2 calcium channels
The fusion of synaptic vesicles (SVs) at the presynaptic transmitter release face is gated by Ca2+ influx from nearby voltage-gated calcium channels (CaVs). Functional studies favor a directExpand
  • 21
  • 3
Rab3a interacting molecule (RIM) and the tethering of pre‐synaptic transmitter release site‐associated CaV2.2 calcium channels
Biochemical and physiological evidence suggest that pre‐synaptic calcium channels are attached to the transmitter release site within the active zone by a molecular tether. A recent study hasExpand
  • 28
  • 2
Slow chemical transmission between dorsal root ganglion neuron somata
Somatic sensory neuron somata are located within the dorsal root ganglia (DRG) and are mostly ensheathed by individual satellite glial cell sheets. It has been noted, however, that a subpopulation ofExpand
  • 18
  • 1
PDLIM5 is not a neuronal CaV2.2 adaptor protein
To the editor: PDLIM5 (postsynaptic density protein–95, discs-large, ZO1, Lin11–Isl-1–Mec-3), formerly known as enigma homolog (ENH) is a ~63-kDa cytoplasmic protein composed of a PDZ domain at the NExpand
  • 9
Transmitter release face Ca2+ channel clusters persist at isolated presynaptic terminals
Ca2+ influx through N‐type Ca2+ channels (CaV2.2) is known to be critical for transmitter release at many synapses. These channels are known to be localized to transmitter release sites, but theirExpand
  • 11
Synaptic Vesicle Capture by Intact CaV2.2 Channels
The fusion of synaptic vesicles (SVs) at the presynaptic transmitter release face is gated by Ca2+ influx from nearby voltage gated calcium channels (CaV). Our early functional studies argued thatExpand
The Calcium Channel Single Channel Conductance Heirarchy is N>L>T at Physiological External Calcium: Implications for Presynaptic Transmitter Release Site Gating
A number of studies support the conclusion that single CaV channels Ca2+ nanodomains gate molecular signaling pathways. Thus, at presynaptic terminals single CaV2.2 channels trigger fusion ofExpand