Fiona J. Clay

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The intracellular signaling mechanisms that specify tissue-specific responses to the interleukin-6 (IL-6) family of cytokines are not well understood. Here, we evaluated the functions of the two major signaling pathways, the signal transducers and activators of transcription 1 and 3 (STAT1/3) and the Src-homology tyrosine phosphatase 2 (SHP2)-Ras-ERK,(More)
INTRODUCTION Acute orthopaedic trauma is a major contributor to the global burden of disease. This study aims to synthesise and summarise current knowledge concerning prognostic factors for return to work and duration of work disability following acute orthopaedic trauma. METHODS A systematic review of prognostic studies was performed. The Medline,(More)
OBJECTIVE To assess the impact of an aging workforce on (1) the incidence of work-related injury or disease and (2) the return-to-work (RTW) process. METHODS Workers' compensation claims (from 2001 to 2004) from Victoria, Australia (n = 59,525) were analyzed. Time off work was defined in terms of time until first RTW, number of workdays compensated, and(More)
To identify the physiological role of Hck, a functionally redundant member of the Src family of tyrosine kinases expressed in myelomonocytic cells, we generated Hck(F/F) "knock-in" mice which carry a targeted tyrosine (Y) to phenylalanine (F) substitution of the COOH-terminal, negative regulatory Y(499)-residue in the Hck protein. Unlike their Hck(-/-)(More)
OBJECTIVE To determine factors associated with return to work following acute non-life-threatening orthopaedic trauma. DESIGN Prospective cohort study. PARTICIPANTS One hundred and sixty-eight participants were recruited and followed for 6 months. The study achieved 89% participant follow-up. METHODS Baseline data were obtained by survey and medical(More)
We have devised a screen for genes from the yeast Saccharomyces cerevisiae whose expression is affected by cell type or by the mating pheromones. From this screen we identified a gene, FUS1, whose pattern of expression revealed interesting regulatory strategies and whose product was required for efficient cell fusion during mating. Transcription of FUS1(More)
BACKGROUND To determine factors predicting the duration of time away from work following acute orthopaedic non life threatening trauma METHODS Prospective cohort study conducted at four hospitals in Victoria, Australia. The cohort comprised 168 patients aged 18-64 years who were working prior to the injury and sustained a range of acute unintentional(More)
UNLABELLED The study quantifies the association between a range of bio-psychosocial factors and the presence of persistent pain, pain severity and pain interfering with normal work activities in a cohort of 168 patients with a range of non-life-threatening orthopaedic injuries. Participants were recruited following presentation to 1 of 4 Victoria hospitals(More)
BACKGROUND Acute orthopedic trauma contributes substantially to the global burden of disease. OBJECTIVES The present systematic review aimed to summarize the current knowledge concerning prognostic factors for the presence of persistent pain, pain severity and pain-related disability following acute orthopedic trauma involving a spectrum of pathologies to(More)
Aim After work-related injury or disease, multiple spells of work absences and unsuccessful return to work (RTW) are common. The purpose of this study was to identify predictors of sustained RTW and work disability recurrences. Methods Australian WorkSafe Victoria claims containing income compensation payments starting between January 1st, 2001 and December(More)