Fiona Hughes

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Previous studies have shown an association between latent adenoviral infection with expression of the adenoviral E1A gene and chronic obstructive pulmonary disease (COPD). The present study focuses on how the adenoviral E1A gene could alter expression of growth factors by human bronchial epithelial (HBE) cells. The data show that connective tissue growth(More)
Several factors are expected to significantly increase stakeholders' interest in healthcare simulation studies in the foreseeable future, e.g., the use of metrics for performance measurement, and increasing patients' expectations. To cater to this, several strategies may have to be implemented in concert, e.g., development of skilled manpower and engagement(More)
In pool boiling and spray cooling the Leidenfrost point marks the transition from nucleate boiling, in which the evaporating liquid is in contact with the surface, and film boiling, in which a layer of vapor separates the fluid from the surface. For a single evaporating drop, the Leidenfrost point occurs when the capillary and gravita-tional forces are(More)
BACKGROUND Human Rhinovirus infection is an important precursor to asthma and chronic obstructive pulmonary disease exacerbations and the Human Viral Challenge model may provide a powerful tool in studying these and other chronic respiratory diseases. In this study we have reported the production and human characterisation of a new Wild-Type HRV-16(More)
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