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PURPOSE Hypoxia is associated with resistance to radiotherapy and chemotherapy and activates transcription factors that support cell survival and migration. We measured the volume of hypoxic tumor and the maximum level of hypoxia in glioblastoma multiforme before radiotherapy with [(18)F]fluoromisonidazole positron emission tomography to assess their impact(More)
MRL/l mice spontaneously develop a hindlimb arthropathy, as well as a number of immunologic abnormalities, including circulating rheumatoid factors. Although previous studies have suggested that this arthropathy is primarily an inflammatory process, we performed a comprehensive histomorphologic study which indicated that inflammation is a late manifestation(More)
OBJECTIVE To identify intrapartum predictors of newborn encephalopathy in term infants. DESIGN Population based, unmatched case-control study. SETTING Metropolitan area of Western Australia, June 1993 to September 1995. SUBJECTS All 164 term infants with moderate or severe newborn encephalopathy; 400 randomly selected controls. MAIN OUTCOME MEASURES(More)
UNLABELLED (18)F-FDG PET images of tumors often display highly heterogeneous spatial distribution of (18)F-FDG-positive pixels. We proposed that this heterogeneity in (18)F-FDG spatial distribution can be used to predict tumor biologic aggressiveness. This study presents data to support the hypothesis that a new heterogeneity-analysis algorithm applied to(More)
OBJECTIVE To ascertain antepartum predictors of newborn encephalopathy in term infants. DESIGN Population based, unmatched case-control study. SETTING Metropolitan area of Western Australia, June 1993 to September 1995. SUBJECTS All 164 term infants with moderate or severe newborn encephalopathy; 400 randomly selected controls. MAIN OUTCOME MEASURES(More)
UNLABELLED 3'-Deoxy-3'-fluorothymidine (FLT), a thymidine analog, is under investigation for monitoring cellular proliferation in gliomas, a potential measure of disease progression and response to therapy. Uptake may result from retention in the biosynthetic pathway or leakage via the disrupted blood-tumor barrier. Visual analysis or static measures of(More)
UNLABELLED Calculation of the glucose metabolic rate (MRGlc) in brain with PET and 2-[18F]fluoro-2-deoxy-D-glucose (FDG) requires knowing the rate of uptake of FDG relative to glucose from plasma into metabolite pools in the tissue. The proportionality factor for this is the FDG lumped constant (LC[FDG]), the ratio of the volumes of distribution of FDG and(More)
UNLABELLED The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MR(glc)) from FDG metabolic rate (MR(FDG)). METHODS LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MR(glc) and MR(FDG) independently using 1-(11)C-glucose and (18)F-FDG with dynamic positron tomographic imaging,(More)
A new approach to the analysis of episodic hormone data is described. The method involves a stochastic model in which measured blood hormone concentration is represented as a convolution of individual pulses, each of which is thought of as the response to a burst of neural activity. Individual pulses are not constrained to occur in a fixed regular pattern(More)
The efficient production of recombinant proteins by Chinese Hamster Ovary (CHO) cells in modern bioprocesses is often augmented by the use of proliferation control strategies. The most common method is to shift the culture temperature from 37 °C to 28-33 °C though genetic approaches to achieving the same effect are also of interest. In this work we used(More)