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A new approach to the analysis of episodic hormone data is described. The method involves a stochastic model in which measured blood hormone concentration is represented as a convolution of individual pulses, each of which is thought of as the response to a burst of neural activity. Individual pulses are not constrained to occur in a fixed regular pattern(More)
Two methodologies for fitting radiotracer models on a pixel-wise basis to PET data are considered. The first method does parameter optimization for each pixel considered as a separate region of interest. The second method also does pixel-wise analysis but incorporates an additive mixture representation to account for heterogeneity effects induced by(More)
Kinetic quantitation of dynamic positron emission tomography (PET) studies via compartmental modeling usually requires the time-course of the radio-tracer concentration in the arterial blood as an arterial input function (AIF). For human and animal imaging applications, significant practical difficulties are associated with direct arterial sampling and as a(More)
Most radiotracers used in dynamic positron emission tomography (PET) scanning act in a linear time-invariant fashion so that the measured time-course data are a convolution between the time course of the tracer in the arterial supply and the local tissue impulse response, known as the tissue residue function. In statistical terms the residue is a life table(More)
PURPOSE Hypoxia is associated with resistance to radiotherapy and chemotherapy and activates transcription factors that support cell survival and migration. We measured the volume of hypoxic tumor and the maximum level of hypoxia in glioblastoma multiforme before radiotherapy with [(18)F]fluoromisonidazole positron emission tomography to assess their impact(More)
PURPOSE The aim of this study is to compare glucose metabolism and hypoxia in four different tumor types using positron emission tomography (PET). (18)F-labeled fluorodeoxyglucose (FDG) evaluates energy metabolism, whereas the uptake of (18)F-labeled fluoromisonidazole (FMISO) is proportional to tissue hypoxia. Although acute hypoxia results in accelerated(More)
The estimation of parameters in radio-tracer models from positron emission tomography (PET) data by nonlinear least squares (NLS) often leads to results with unacceptable mean square error (ME) characteristics. The introduction of constraints on parameters has the potential to address this problem. We examine a ridge-regression technique that augments the(More)
UNLABELLED Studies in animals and postmortem human brain tissue support a role for P-glycoprotein in clearance of cerebral β-amyloid across the blood-brain barrier (BBB). We tested the hypothesis that BBB P-glycoprotein activity is diminished in Alzheimer disease (AD) by accounting for an AD-related reduction in regional cerebral blood flow (rCBF). (More)