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Lipid peroxidation has been reported to play an important role in spinal cord injury (SCI). Erythropoietin (EPO) is a hematopoietic growth factor that stimulates proliferation and differentiation of erythroid precursor cells and is also known to exert neurotrophic activity in the central nervous system. The purpose of this study was to investigate the(More)
Spinal cord injury (SCI) involves a series of pathological events. Abnormal sodium influx has been implicated as one of the key events in the pathophysiology of the SCI. Pharmacological blockade of sodium channels can reduce secondary injury and increase recovery from trauma. The aim of the present study was to show the neuroprotective effect of phenytoin,(More)
OBJECT The purpose of this study was to investigate the effect of mexiletine on lipid peroxidation and on ultrastructural findings after induced spinal cord injury (SCI). The authors also compared the activity of mexiletine to that of the well-known antioxidant, methylprednisolone sodium succinate (MPSS). METHODS Wistar rats were divided into seven(More)
OBJECTIVE To demonstrate the changes in microvascular permeability occurring in association with graded acute spinal cord injury and to determine whether tissue Evans blue content is a useful indicator of the severity of spinal cord injury. The study also aimed to test the ability of the Evans blue method to demonstrate secondary injury after spinal cord(More)
BACKGROUND Evidence regarding the vascular endothelial growth factor A (VEGFA) as a potent mediator of angiogenesis and inflammation in psoriasis has revealed variations in this gene as surrogate markers of psoriasis. OBJECTIVE VEGFA gene polymorphisms (-1540 C/A, -1512 Ins18, -460 T/C, and +405 C/G) in psoriasis susceptibility in Turkish population were(More)
Object: Free oxygen radicals playa major role in the pathophysiology of c~ntral nervous system (CNS) trauma, neurodegeneration and aging. Aminophylline, an antiasthmatic drug, was shown to exert some free radical scavenging effect on lung tissue. The purpose of this study was to investigate the free radical scavenging effect of aminophylline on CNS tissues.(More)
INTRODUCTION The emergency laboratory in Hacettepe University Hospitals receives specimens from emergency departments (EDs), inpatient services and intensive care units (ICUs). The samples are accepted according to the rejection criteria of the laboratory. In this study, we aimed to evaluate the sample rejection ratios according to the types of(More)
Sc) has been identified as the infectious agent in a group of neurodegenerative diseases called transmissible spongiform encephalopathies (TSEs) or prion diseases (1). One of the TSEs, Creutzfeldt-Jakob disease (CJD), is of particular interest, because it has been the cause of a food-originated epidemic in Europe. CJD was formerly described as a sporadic or(More)