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  • Valeria Naim, Therese Wilhelm, Michelle Debatisse, Filippo Rosselli
  • Biology, Medicine
  • Nature Cell Biology
  • 2013 (First Published: 1 August 2013)
  • Chromosomal instability (CIN) is a hallmark of tumour initiation and progression. Some genomic regions are particularly unstable under replication stress, notably common fragile sites (CFSs) whoseContinue Reading
  • Pietro Pichierri, Filippo Rosselli, Annapaola Franchitto
  • Biology, Medicine
  • Oncogene
  • 2003 (First Published: 1 March 2003)
  • Werner's syndrome (WS) is an autosomal recessive disorder, characterized at the cellular level by genomic instability in the form of variegated translocation mosaicism and extensive deletions.Continue Reading
  • Emilie Renaud, Aurélia Barascu, Filippo Rosselli
  • Biology, Medicine
  • Nucleic acids research
  • 2016 (First Published: 29 January 2016)
  • To rescue collapsed replication forks cells utilize homologous recombination (HR)-mediated mechanisms to avoid the induction of gross chromosomal abnormalities that would be generated byContinue Reading
    We have previously shown an unbalanced cytokine production in Fanconi anemia (FA) cells, ie, an underproduction of interleukin 6 (IL-6) during growth. Among a number of cytokines analyzed, the onlyContinue Reading