Filippo Carlucci

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Hematopoietic stem cell (HSC) gene therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID) has shown limited clinical efficacy because of the small proportion of engrafted genetically corrected HSCs. We describe an improved protocol for gene transfer into HSCs associated with nonmyeloablative conditioning. This protocol was(More)
Rottlerin is a natural product isolated from Mallotus philippinensis. This polyphenolic compound, originally described as a selective inhibitor of PKCδ, can inhibit many other PKC-unrelated kinases and has a number of biological actions, including mitochondrial uncoupling effects. We recently found that Rottlerin inhibits the transcription factor nuclear(More)
Adenosine Deaminase (ADA) deficiency is an autosomal recessive variant of severe combined immunodeficiency (SCID) caused by systemic accumulation of ADA substrates. Neurological and behavioral abnormalities observed in ADA-SCID patients surviving after stem cell transplantation or gene therapy represent an unresolved enigma in the field. We found(More)
  • Barutta F, Piscitelli F Pinach, Bruno G, Gambino R, Rastaldi Mp, Salvidio G +94 others
  • 2011
Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy. Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Nephrin expression in adult rodent central nervous system and its interaction with glutamate receptors. mTORC1(More)
BACKGROUND The diagnosis and monitoring of severe combined immunodeficiency disease (SCID) attributable to adenosine deaminase (ADA) deficiency requires measurements of ADA, purine nucleoside phosphorylase (PNP), and S-adenosyl-L-homocysteine-hydrolase (SAHH) activity and of deoxyadenosine metabolites. We developed capillary electrophoresis (CE) methods for(More)
The authors carried out an experimental study to compare the regeneration of nerves repaired with human fibrin glue and those sutured with nylon. The experiments were performed on rat peroneal nerves; the degree of regeneration was assessed by the neurophysiological strain gauge method, which involved recording the intensity of isometric contraction of the(More)
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