Filipe Marques

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A method is proposed whereby values for Service Level Objectives (SLOs) of an SLA can be chosen to reduce the sum IT infrastructure cost plus business financial loss. Business considerations are brought into the model by including the business losses sustained when IT components fail or performance is degraded. To this end, an impact model is fully(More)
BACKGROUND The emergence of drug resistant typhoid fever is a major public health problem, especially in Asia. An oral single dose typhoid vaccine would have major advantages. M01ZH09 is a live oral single dose candidate typhoid vaccine containing Salmonella enterica serovar Typhi (Ty2 aroC(-)ssaV(-)) ZH9 with two independently attenuating deletions.(More)
— A methodology for designing data center infrastructure for E-commerce sites is developed. It differs from existing methodologies in that it evaluates and compares alternative designs from a business perspective, that is, by evaluating the business impact (financial loss) imposed by imperfect infrastructure. The methodology provides the optimal(More)
A business-driven approach to designing service level agreements in an e-commerce environment is proposed. In contrast to conventional SLA design approaches, the one proposed better captures the linkage between service provider and service client by considering the negative business impact (business loss) originated from IT infrastructure failures and(More)
This work proposes a business-oriented approach to designing IT infrastructure in an e-commerce context subject to load surges. The main difference between the proposed approach and conventional ones is that it includes the negative business impact - loss - incurred due to IT infrastructure failures and performance degradation. The approach minimizes the(More)
Visceral leishmaniasis is a severe and potentially fatal disease caused by protozoa of the genus Leishmania, transmitted by phlebotomine sandflies. In Europe and the Mediterranean region, L. infantum is the commonest agent of visceral leishmaniasis, causing a wide spectrum of clinical manifestations, including asymptomatic carriage, cutaneous lesions and(More)
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