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Primary ovarian insufficiency (POI) is a critical fertility defect characterized by an anticipated and silent impairment of the follicular reserve, but its pathogenesis is largely unexplained. The frequent maternal inheritance of POI together with a remarkable dependence of ovarian folliculogenesis upon mitochondrial biogenesis and bioenergetics suggested… (More)
This short communication describes the delayed onset of premature ovarian failure (POF) in some young patients, between 5 to 24 months after operative laparoscopy for ovarian endometriosis. This complication apparently does not have a link with traditional risk factors for POF. In view of this observation, further and consistent clinical investigations are… (More)
The correlation between the sex steroids and the immune system is already known but the relationships between testosterone, progesterone, estradiol, cortisol and the immune system are still controversial. The Authors have studied lymphocytes subset in ten women with polycystic ovarian disease (PCOD); it was observed: 1) a decrease of T8 in 64% and of… (More)
Female smokers experienced menopause significantly (P <or= 0.000001) earlier than non-smokers (47.1 +/- 3.3 versus 49.4 +/- 3.6 years, mean age at menopause +/- SD) and the prevalence of cigarette smoking is more frequent in females with ovarian failure before 46 years of age. These data are consistent with a possible detrimental effect of cigarette smoking… (More)
A compared study of neurovegetative modifications (following stress stimula) and of psychopathological aspects in patients affected by amenorrhea was carried out. Such an integrated approach is useful for a better definition of clinical characteristic and for a selection of a suitable therapeutic approach.
The authors refer the results of their study in 15 healthy women in whom 24-hours serum melatonin (MT) and cortisol (F) were assayed by RIA method. Both hormones showed a clear circadian rhythm: Melatonin reached the highest values between 24.00 and 04.00 while cortisol were at the lowest values. The relationships between Corticotropin Releasing Factor… (More)
The Authors report the persistence of regular menses in a very old woman. Although in the absence of a pulsatile gonadotropin pattern the patient showed estradiol levels typical of the reproductive age.
In 35 women, 16-32 years old (average age 24) affected by hirsutism associated to menstrual disorders as oligomenorrhea or secondary amenorrhea, the real utility of testosterone's free fraction assay (FT) in comparison with conventional hormonal assays has been valued. The free testosterone (FT) resulted the most frequently elevated hormone (69%). The… (More)