Filiberto Di Gennaro

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BACKGROUND AND OBJECTIVE The tracer tachnetium-99m-2-methoxy-isobutyl-isonitrile (Tc99m-sestaMIBI) has recently been shown to concentrate in some neoplastic tissues, including myeloma. We investigated the diagnostic capacity and limits of this procedure in tracing focal myeloma lesions, and compared them with those of conventional radiological procedures(More)
BACKGROUND Musculoskeletal disorders are the most common extra-intestinal manifestation of inflammatory bowel disease (IBD). Wide ranges of prevalence have been reported depending on the criteria used to define spondylarthropathy and on the selection of patients. We aimed to evaluate the prevalence and clinical spectrum of musculoskeletal manifestations in(More)
8063 Background: The extra-domain A1 (ED-A1) of tenascin-C is a highly expressed component of the tumor extracellular matrix and constitutes a valuable target for radionuclide therapy. Tenarad is a human antibody which is capable of recognizing ED-A1, has been labeled with I-131 and is expressed as small immunoprotein (SIP) for improving its biodistribution(More)
OBJECTIVE To assess whether granulocyte colony-stimulating factor (G-CSF) treatment induces a sustained benefit on adverse remodelling in patients with large anterior ST-elevation myocardial infarction (STEMI) and left ventricular (LV) dysfunction after successful reperfusion. METHODS The STEM-AMI Trial was a prospective, placebo-controlled, multicentre(More)
OBJECTIVE Hyperferritinemia is frequent in chronic liver diseases of any cause, but the extent to which ferritin truly reflects iron stores is variable. In these patients, both liver iron and fat are found in variable amount and association. Liver biopsy is often required to quantify liver fat and iron, but sampling variability and invasiveness limit its(More)
e12502 Background: The extradomain B (ED-B) of fibronectin (FN) is a highly expressed marker of tumor angiogenesis and thus provides a molecular target for radioimmunotherapy (RIT). The RIT agent 131I-L19SIP is a small immunoprotein (SIP) labeled with I-131 recognizing the ED-B domain. Previous phase I/II 131I-L19SIP RIT studies have have shown efficacy in(More)
The Authors report the case of a patient who underwent resection of a huge anterior mediastinal mass, revealing to be a necrotic thymoma. The patient had been previously submitted to surgical biopsies of the mass yielding non-diagnostic results due to extensive necrosis. A sternotomy was then performed to resect the mediastinal mass originating from the(More)
Recent studies show that interaction between LN (heterotrimeric protein formed by a3/b3/g2 chains) and cancer cells plays an important role in tumor invasion, also in colorectal cancer. The overall survival was significantly worse in patients with free peritoneal cancer cells(FPTCs): detection of FPTCs after curative surgery is a challenge, because could(More)
A case of primary biliary cirrhosis occurred during the first quarter of pregnancy in a 29-years-old primipara is described. Possible relationships with a former anti-hepatitis B vaccination and with positive familiarity reduction of IgA are discussed. Follow-up to the patient after two years therapy with colchicine 1 mg a day is also described.