Fernando Vázquez

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Polymorphism in genes encoding T-cell regulatory proteins and cytokines may influence inflammation and cancer development via regulation of antitumor immune response. In the current study we analyzed genotypic frequencies of cytotoxic T-lymphocyte antigen-4 (CTLA-4)/CT60, CTLA-4/A49G, interleukin (IL)-4, and IL-10 polymorphisms in 117 renal cell carcinoma(More)
Vaginal microbiota, mainly comprised of Lactobacillus crispatus, L. jensenii and L. gasseri, protect the mucosa against the establishment of pathogenic microorganisms through three complementary mechanisms: a) specific adherence to the epithelium, which blocks colonization of pathogens, b) production of antimicrobial compounds, and c) co-aggregation with(More)
Anaerobic bacteremia (116 cases) represented 5.4% of the total cases of bacteremia in the Hospital Nuestra Señora de Covadonga of Oviedo, Spain, during a five-year period (1981-1985). Microbiologic data for all 116 cases and clinical data for 63 patients were analyzed. A total of 129 isolates were identified as gram-negative bacilli (45.7%), gram-positive(More)
Electron tomography allows elucidation of the molecular architecture of complex biological specimens. Weighted backprojection (WBP) is the standard reconstruction method in the field. In this work, three-dimensional reconstruction with WBP is addressed from a matrix perspective by formulating the problem as a set of sparse matrix-vector products, with the(More)
PURPOSE Vascular endothelial growth factor (VEGF) plays a central role in promoting angiogenesis and is over-expressed in renal cell cancer (RCC). Published data on the association between polymorphisms of vascular endothelial growth factor (e.g., -2578C/A [rs699947], -460T/C [rs833061], +405C/G [rs2010963], and +936C/T [rs3025039]) and the risk of renal(More)
We report initial experience with the use of a new intracranial stent, the Leo microstent in combination with detachable coils in treatment of patients with wide-necked cerebral aneurysms. The Leo stent represents a significant advance in the vascular treatment of intracranial aneurysm with high radial force and an easy delivery system. It is a feasible,(More)
Three strains of Lactobacillus, identified as Lactobacillus acidophilus, Lactobacillus gasseri, and Lactobacillus jensenii, were selected from among 70 isolates from the vaginas of healthy premenopausal women for properties relevant to mucosal colonization or antagonism. All three self-aggregated and adhered to epithelial vaginal cells, displacing(More)
To test efficacy and tolerability of non-platinum regimens for advanced non-small-cell lung cancer (NSCLC). Chemonaive patients with measurable stage IIIB/IV NSCLC treated with gemcitabine and cisplatin (GC), or gemcitabine and docetaxel (GD), maximumsix cycles in a phase IIB trial. A total of 108 patients were randomized. Response rates (GC vs. GD,(More)
Two extensions of the original Wilson’s editing method are introduced in this paper. These new algorithms are based on estimating probabilities from the k-nearest neighbor patterns of an instance, in order to obtain more compact edited sets while maintaining the classification rate. Several experiments with synthetic and real data sets are carried out to(More)
BACKGROUND Information is scarce on the impact of the clinical electronic record on the frequency and severity of medication errors in acute geriatric patients. MATERIAL AND METHODS An analytical and descriptive pre-post study was conducted on the implementation of computerized provider order entry systems (CPOE), over a 6 year period. A voluntary(More)