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INTRODUCTION While non-invasive ventilation aimed at avoiding intubation has become the modality of choice to treat mild to moderate acute respiratory acidosis, many severely acidotic patients (pH <7.20) still need intubation. Extracorporeal veno-venous CO2 removal (ECCO2R) could prove to be an alternative. The present animal study tested in a systematic(More)
UNLABELLED Atelectasis in the dependent lung during one-lung ventilation (OLV) impairs arterial oxygenation and increases dead space. We studied the effect of an alveolar recruitment strategy (ARS) on gas exchange and lung efficiency during OLV by using the single-breath test of CO(2) (SBT-CO(2)). Twelve patients undergoing thoracic surgery were studied at(More)
BACKGROUND We conducted this study to determine whether pulse oximetry and volumetric capnography (VCap) can determine the opening and closing pressures of lungs of anesthetized morbidly obese patients. METHODS Twenty morbidly obese patients undergoing laparoscopic bariatric surgery with capnoperitoneum were studied. A lung recruitment maneuver was(More)
BACKGROUND The influence of hydroxyethyl starch (HES) solutions on renal function is controversial. We investigated the effect of HES administration on renal function in critically ill patients enrolled in a large multicentre observational European study. METHODS All adult patients admitted to the 198 participating intensive care units (ICUs) during a(More)
Imbalances in regional lung ventilation, with gravity-dependent collapse and overdistention of nondependent zones, are likely associated to ventilator-induced lung injury. Electric impedance tomography is a new imaging technique that is potentially capable of monitoring those imbalances. The aim of this study was to validate electrical impedance tomography(More)
There is a strong clinical demand for devices allowing continuous non-invasive monitoring of central blood pressure (BP). In the state of the art a new family of techniques providing BP surrogates based on the measurement of the so-called pulse wave velocity (PWV) has been proposed, eliminating the need for inflation cuffs. PWV is defined as the velocity at(More)
PURPOSE Bohr's dead space (VD(Bohr)) is commonly calculated using end-tidal CO(2) instead of the true alveolar partial pressure of CO(2) (PACO(2)). The aim of this work was to validate VD(Bohr) using PACO(2) derived from volumetric capnography (VC) against VD(Bohr) with PACO(2) values obtained from the standard alveolar air formula. METHODS Expired gases(More)
Dead space is the portion of a tidal volume that does not participate in gas exchange because it does not get in contact with blood flowing through the pulmonary capillaries. It is commonly calculated using volumetric capnography, the plot of expired carbon dioxide (CO(2)) versus tidal volume, which is an easy bedside assessment of the inefficiency of a(More)
A capnodynamic calculation of effective pulmonary blood flow includes a lung volume factor (ELV) that has to be estimated to solve the mathematical equation. In previous studies ELV correlated to reference methods for functional residual capacity (FRC). The aim was to evaluate the stability of ELV during significant manipulations of cardiac output (CO) and(More)
In a previous study a new capnodynamic method for estimation of effective pulmonary blood flow (COEPBF) presented a good trending ability but a poor agreement with a reference cardiac output (CO) measurement at high levels of PEEP. In this study we aimed at evaluating the agreement and trending ability of a modified COEPBF algorithm that uses expiratory(More)