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Finding the optimal solution to NP-hard problems requires at least exponential time. Thus, heuristic methods are usually applied to obtain acceptable solutions to this kind of problems. In this paper we propose a new type of heuristic algorithms to solve this kind of complex problems. Our algorithm is based on river formation dynamics and provides some(More)
The objective of this study was to investigate bacterial resistance trends, infection sites and the relationship between resistance and admittance to the intensive care unit (ICU). A total of 53,316 bacteria identified between 1999 and 2008 were evaluated. Multidrug resistance was characterized when gram-negative bacilli (GNB) presented resistance to two or(More)
This paper presents a practical evaluation and comparison of three state-of-the-art parallel functional languages. The evaluation is based on implementations of three typical symbolic computation programs, with performance measured on a Beowulf-class parallel architecture. We assess three mature parallel functional languages: PMLS, a system for implicitly(More)
BACKGROUND Nosocomial infections caused by Pseudomonas aeruginosa presenting resistance to beta-lactam drugs are one of the most challenging targets for antimicrobial therapy, leading to substantial increase in mortality rates in hospitals worldwide. In this context, P. aeruginosa harboring acquired mechanisms of resistance, such as production of(More)
Eden is a parallel functional language which extends Haskell with new expressions to define and instantiate processes. These extensions allow the easy definition of parallel process topologies as higher order functions. Unfortunately, by only using process abstractions and instantiations it is not possible to implement non-hierarchical topologies, as(More)
The aim of this study was to investigate the presence and prevalence of bla(TEM), bla(SHV), and bla(CTX-M) and bla(GES)-like genes, responsible for extended spectrum beta-lactamases (ESBLs) production in clinical isolates of Klebsiella pneumoniae collected from a Brazilian tertiary care hospital. Sixty-five ESBL producing K. pneumoniae isolates, collected(More)
Community-Acquired Pneumonia (CAP) is a major public health problem. In Brazil it has been estimated that 2,000,000 people are affected by CAP every year. Of those, 780,000 are admitted to hospital, and 30,000 have death as the outcome. This is an open-label, non-comparative study with the purpose of evaluating efficacy, safety, and tolerability levels of(More)