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Cannabinoid receptors regulate Ca2+ signals and insulin secretion in pancreatic β-cell
Insulin is the main hormone involved in the regulation of glycaemia, its impaired secretion is a hallmark of type I and type II diabetic individuals. Additionally, insulin is involved in lipogenesisExpand
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Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole – LH 21
The present study evaluates the pharmacological profile of the new neutral cannabinoid CB1 receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole -LH-21- on feedingExpand
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The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats
Anandamide and oleoylethanolamide (OEA) are lipid mediators that regulate feeding and lipid metabolism. While anandamide, a cannabinoid CB1 receptor agonist, promotes feeding and lipogenesis,Expand
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Nicotine in alcohol deprivation increases alcohol operant self-administration during reinstatement
Tobacco and alcohol are highly co-abused by humans. Most experimental studies have evaluated ethanol consumption in animals exposed concomitantly to nicotine. However, little is known regarding theExpand
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Oleoylethanolamide: Effects on hypothalamic transmitters and gut peptides regulating food intake
Recently, it has been described the role of fatty acid ethanolamides in the control of feeding behavior. Oleoylethanolamide (OEA) is a member of this family of lipid mediators regulating feeding. OEAExpand
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Long-Term Effects of Mouse Intracytoplasmic Sperm Injection with DNA-Fragmented Sperm on Health and Behavior of Adult Offspring1
Abstract Genetic and environmental factors produce different levels of DNA damage in spermatozoa. Usually, DNA-fragmented spermatozoa (DFS) are used with intracytoplasmic sperm injection (ICSI)Expand
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Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1
Recent studies suggest that blockade of cannabinoid CB1 receptors suppresses feeding, an effect observed in humans treated with the cannabinoid CB1 antagonist Rimonabant. A cross-talk betweenExpand
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Oleoylethanolamide: a new player in peripheral control of energy metabolism. Therapeutic implications
The incidence of obesity and related metabolic disorders is currently increasing at an alarming rate in modern society. Therefore, the development of effective antiobesity therapies represents a highExpand
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Plasma concentrations of oleoylethanolamide in a primary care sample of depressed patients are increased in those treated with selective serotonin reuptake inhibitor-type antidepressants
&NA; Oleoylethanolamide (OEA) is a non‐cannabinoid acylethanolamide with multiple physiological roles that has been proposed to have antidepressant‐like activity in preclinical models. OEA sharesExpand
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Oleoylethanolamide, a ligand of the peroxisome proliferator-activated receptor alpha, prevents liver injury and oxidative stress induced by Tween 20
Oleoylethanolamide (OEA) is an endogenous agonist of peroxisome proliferator-activated receptor al- pha (PPARα), a nuclear receptor involved in the regulation of lipid metabolism. In the presentExpand
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