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From dioxime oxalates to dihydropyrroles and phenanthridines via iminyl radicals.

• Fernando Portela-Cubillo, Eoin M Scanlan, Jackie S Scott, John C Walton
• Chemical communications
• 2008

Dioxime oxalates are useful precursors for the clean generation of iminyl radicals by sensitised UV photolysis and can be adapted for serviceable preparations of 3,4-dihydro-2H-pyrroles and… (More)

Microwave-assisted syntheses of N-heterocycles using alkenone-, alkynone- and aryl-carbonyl O-phenyl oximes: formal synthesis of neocryptolepine.

• Fernando Portela-Cubillo, Jackie S Scott, John C Walton
• The Journal of organic chemistry
• 2008

This research aimed to provide a new and "clean" synthetic method that would enable both known and novel N-heterocycles to be prepared efficiently. O-Phenyl oximes were found to be excellent… (More)

Microwave-assisted preparations of dihydropyrroles from alkenone O-phenyl oximes.

• Fernando Portela-Cubillo, Jackie S Scott, John C Walton
• Chemical communications
• 2007

Microwave irradiation of alkenone O-phenyl oximes produces iminyl radicals that ring close to yield dihydropyrrole derivatives; pyrroles and pyridines can be obtained from related precursors.

Microwave-promoted syntheses of quinazolines and dihydroquinazolines from 2-aminoarylalkanone O-phenyl oximes.

• Fernando Portela-Cubillo, Jackie S Scott, John C Walton
• The Journal of organic chemistry
• 2009

A wide range of biologically active compounds contain the quinazoline ring system. A new free-radical-based method of making functionalized quinazolines is described, which relies on… (More)

Thermal rearrangement of indolyl oxime esters to pyridoindoles.

• Fernando Portela-Cubillo, Brian Surgenor, R. Alan Aitken, John C Walton
• The Journal of organic chemistry
• 2008

Acyl oximes derived from a variety of indolylalkanones underwent a ring closure sequence during FVP to afford 9H-pyrido[2,3-b]indoles. Unlike UV light promoted reactions of oxime esters, the… (More)

5-Exo-cyclizations of pentenyliminyl radicals: inversion of the gem-dimethyl effect.

• Fernando Portela-Cubillo, Rafael Alonso-Ruiz, Diego Sampedro, John C Walton
• The journal of physical chemistry. A
• 2009

This paper describes how the rates of 5-exo-ring closures of unsaturated iminyl radicals to pyrrolomethyl radicals respond to substituents in the pentenyl chain and at the C=N bond. Benzyl- and acyl… (More)

A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids.

• Shi-Guang Li, Fernando Portela-Cubillo, Samir Z Zard
• Organic letters
• 2016

A radical based synthesis of a broad variety of protected enantiopure α-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-α-amino… (More)

2-(Aminoaryl)alkanone O-phenyl oximes: versatile reagents for syntheses of quinazolines.

• Fernando Portela-Cubillo, Jackie S Scott, John C Walton
• Chemical communications
• 2008

Microwave irradiations of 2-(aminoaryl)alkanone O-phenyl oximes and carbonyl compounds generate iminyl radicals in company with imines; iminyl on imine ring closure yields dihydroquinazolines or… (More)

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