Fernando Otaviano Campos

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Fibrosis is thought to play an important role in the formation and maintenance of atrial fibrillation (AF). The propensity of fibrosis to increase AF vulnerability depends not only on its amount, its texture plays a crucial role as well. While the detection of fibrotic tissue patches in the atria with extracellular recordings is feasible based on the(More)
Advanced medical imaging technologies provide a wealth of information on cardiac anatomy and structure at a paracellular resolution, allowing to identify microstructural discontinuities which disrupt the intracellular matrix. Current state-of-the-art computer models built upon such datasets account for increasingly finer anatomical details, however,(More)
Cardiac modeling is here to stay. Computer models are being used in a variety of ways and support the tests of drugs, the development of new medical devices and non-invasive diagnostic techniques. Computer models have become valuable tools for the study and comprehension of the complex phenomena of cardiac electrophysiology. However, the complexity and the(More)
The modeling of the electrical activity of the heart is of great medical and scientific interest, because it provides a way to get a better understanding of the related biophysical phenomena, allows the development of new techniques for diagnoses and serves as a platform for drug tests. The cardiac electrophysiology may be simulated by solving a partial(More)
Acetylcholinesterase (AChE) molecular forms were studied during mouse brain development. Mouse embryos expressed a monomeric (G1) and a tetrameric (G4) AChE form. Our results indicate that G4 AChE expressed at embryonic day (ED) 9 and ED15 could be purified by acridinium-Sepharose chromatography and shared similar biochemical and kinetic properties with the(More)
AIMS Premature ventricular complexes (PVCs) due to spontaneous calcium (Ca) release (SCR) events at the cell level can precipitate ventricular arrhythmias. However, the mechanistic link between SCRs and PVC formation remains incompletely understood. The aim of this study was to investigate the conditions under which delayed afterdepolarizations resulting(More)
Thin-walled cardiac tissue samples superfused with oxygenated solutions are widely used in experimental studies. However, due to decreased oxygen supply and insufficient wash out of waste products in the inner layers of such preparations, electrophysiological functions could be compromised. Although the cascade of events triggered by cutting off perfusion(More)