Fernando Mejia-Sanchez

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In Villa Guerrero municipality, floriculture is their first economic activity; there are intensively applied different pesticides alone and in mixtures. They fumigate every day, every second or third day, and men, women, children and third age people participate. The use of prohibited or restricted pesticides such as Tamaron, Temik and Curacron in(More)
The aim of this study was to evaluate the genotoxicity induced by cyclophosphamide-adriamycin treatment in breast cancer patients through the frequencies of Sister Chromatid Exchange (SCE), Replication Index (RI), Mitotic Index (MI) and Cell Proliferation Index (CPI) and to study the possible association between biomarkers of genotoxicity and the early(More)
The Glutathione S-transferase is supergene family polymorphic involved in Phase II metabolism. Participate together in the detoxification of xenobiotics. There are few reports where these set of polymorphism of GSTs genes of the same individual are studied. These polymorphisms can be used as biomarkers for predicting disease risk or response to treatment.(More)
Birth defects are the number one cause of child mortality worldwide and in 2010 it was the second cause in Mexico. Congenital malformations are a public health issue, because they cause infant mortality, chronic disease and disability. The origin can be genetic, environmental or unknown causes. Among environmental contaminants, pesticides stand out. In this(More)
Glutathione S-transferases (GSTs) comprise a number of genes that codify for a group of isoenzymes that participate in phase II xenobiotic detoxification by means of conjugation with glutathione, producing hydrosoluble compounds. It has been demonstrated that some pesticides are substrates for GST isoenzymes. Floriculture is one of the main economic(More)
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