Fernando Mario Ramirez

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It is a principal open question whether noninvasive imaging methods in humans can decode information encoded at a spatial scale as fine as the basic functional unit of cortex: cortical columns. We addressed this question in five magnetoencephalography (MEG) experiments by investigating a columnar-level encoded visual feature: contrast edge orientation. We(More)
Knowledge about the principles that govern large-scale neural representations of objects is central to a systematic understanding of object recognition. We used functional magnetic resonance imaging (fMRI) and multivariate pattern classification to investigate two such candidate principles: category preference and location encoding. The former designates(More)
We previously proposed that DNA recombination/repair processes play a role in memory formation. Here, we examined the possible role of the fen-1 gene, encoding a flap structure-specific endonuclease, in memory consolidation of conditioned taste aversion (CTA). Quantitative real-time PCR showed that amygdalar fen-1 mRNA induction was associated to the(More)
Humans recognize faces and objects with high speed and accuracy regardless of their orientation. Recent studies have proposed that orientation invariance in face recognition involves an intermediate representation where neural responses are similar for mirror-symmetric views. Here, we used fMRI, multivariate pattern analysis, and computational modeling to(More)
We studied single and multi-unit activity recorded with tetrodes, from the left auditory cortex of awake chinchillas while they performed a frequency discrimination task. Auditory stimuli were preceded by a silent visual cue. We examined firing rates and first-spike latencies of 181 units in the presence and absence of the visual cue. To discard possible(More)
To study the biology of regulators of G-protein signaling (RGS) proteins and to facilitate the identification of small molecule modulators of RGS proteins, the authors recently developed an advanced yeast 2-hybrid (YTH) assay format for GalphaZ and RGS-Z1. Moreover, they describe the development of a multiplexed luciferase-based assay that has been(More)
OBJECTIVES The objectives of this study were to evaluate the effect of reimplanting a cochlear implant electrode in animal normal-hearing cochlea to propose measures that may prevent cochlear injury and, given its close phylogenetic proximity to humans, to evaluate the macaque as a model for electroacoustic stimulation. DESIGN Simultaneous, bilateral(More)
Mitral valve regurgitation is a challenging clinical condition that is frequent, highly varied, and poorly understood. While the causes of mitral regurgitation are multifactorial, how the hemodynamics of regurgitation impact valve tissue remodeling is an understudied phenomenon. We employed a pseudo-physiological flow loop capable of long-term organ culture(More)
Reproduction in whole or in part of this document by any means without prior written permission by the publishers is strictly prohibited Garrido, María, ed. authors expressed herein do not necessarily state or reflect those of CIS or the University of Washington. This study is supported by a grant from Microsoft Community Affairs under the Unlimited(More)