Fernando Huerta

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The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38alpha is reported. The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the(More)
Maneuvers that reflexly increase vagal tone were deployed to terminate the tachycardia in 68 consecutive patients with paroxysmal supraventricular tachycardia. The order and success rate of the protocol was as follows: 57 episodes were terminated with carotid sinus pressure alone or after pretreatment with edrophonium, 5 were terminated with the Valsalva(More)
The present study refers to six patients in whom an A-V reciprocal rhythm could be documented; in four cases it took the form of sustained tachycardia. None of the patients showed any ECG feature of ventricular pre-excitation (PR interval of more than 0.12 sec. and normal QRS configuration). The extrastimulus method showed, at first, that the A-V conduction(More)
The objective of this paper is to analyse the influence of a non-ideal grid over hysteresis controllers of converters connected to the grid through both L and LCL filters. The paper will describe the different possible configurations in both cases, analysing the effect of a general R-L grid. Limit values for both grid inductance and resistance are given for(More)
BACKGROUND Few patients who present with dysphagia from esophageal cancer are curable. The rates of surgical resecability are low and the reported 5-yr survival rates are < 10%. Nonsurgical, endoscopic palliation of obstructing gastrointestinal cancers has became popular with stents, Nd: YAG laser, BICAP tumor probe, self-expanding metallic stents. Because(More)
The incidence and possible mechanism of early spontaneous termination of paroxysmal supraventricular tachycardia was studied in 20 consecutive patients. Episodes of induced tachycardia that terminated spontaneously within the 1st minute after initiation were included. Tachycardias ending spontaneously were associated with a reproducible course of(More)
Neurons in the insular cortex have recently been shown to innervate medullary autonomic nuclei such as the nucleus tractus solitarii (NTS). The present study examines the effect of lesioning the insular cortex on baroreceptor-heart rate reflex in conscious rats. We did this by occluding the stem of the left proximal middle cerebral artery which causes a(More)
Neurones in the insular cortex have been shown to innervate medullary autonomic nuclei. Occlusion of the stem of the left proximal middle cerebral artery in rats caused a lesion in the insular and adjacent lateral frontoparietal cortices. Nine and 10 days after lesioning or sham operation, we examined the relationship between mean blood pressure and the(More)
This paper describes a communication architecture for a digital controller based on DSP-FPGA to be used in power electronic systems. For high rate transmissions, the proposed architecture has an USB bus implemented with a minimum use of the DSP core, using enhanced direct memory access and external memory interface modules of a TMS320C6713 high performance(More)