Fernando Gomez

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Identifying the molecular targets for the beneficial or detrimental effects of small-molecule drugs is an important and currently unmet challenge. We have developed a method, drug affinity responsive target stability (DARTS), which takes advantage of a reduction in the protease susceptibility of the target protein upon drug binding. DARTS is universally(More)
Studies with the nematode model Caenorhabditis elegans have identified conserved biochemical pathways that act to modulate life span. Life span can also be influenced by the composition of the intestinal microbiome, and C. elegans life span can be dramatically influenced by its diet of Escherichia coli. Although C. elegans is typically fed the standard OP50(More)
OBJECTIVE This study examines the associations between activity restriction related to fear of falling and sociodemographic and health factors among people aged 60 and older living in the Colombian Andes mountains. METHOD The sample includes 1,668 community-living participants. Outcomes included no fear of falling, fear of falling alone, or activity(More)
Culture-independent molecular methods based on the amplification, cloning and sequencing of small-subunit (SSU) rRNA genes are a powerful tool to study the diversity of prokaryotic and eukaryotic microorganisms for which morphological features are not conspicuous. In recent years, molecular data from environmental surveys have revealed several clades of(More)
BACKGROUND This study aimed to estimate the prevalence and associated factors related to frailty, by Fried criteria, in the elderly population in a rural area in the Andes Mountains, and to analyze the relationship of these with comorbidity and disability. METHODS A cross-sectional study was undertaken involving 1878 participants 60 years of age and(More)
BACKGROUND The Life-Space Assessment (LSA) instrument of the University of Alabama and Birmingham study is a useful and innovative measure of mobility in older populations. The purpose of this article was to assess the reliability, construct and convergent validity of the LSA in Latin American older populations. METHODS In a cross-sectional study, a total(More)
This study presents an evaluation of WordNet-based semantic similarity and relatedness measures in tasks focused on concept similarity. Assuming similarity as distinct from relatedness, the goal is to fill a gap within the current body of work in the evaluation of similarity and relatedness measures. Past studies have either focused entirely on relatedness(More)
During the mid-1970s, an AIM research group directed by Professor B. Chandrasekaran was initiated at Ohio State University. Fernando Gomez was a graduate student at the time and was involved in the group's work on MDX, a program for the diagnosis of liver disease. That system provided an experimental environment in which many of the ideas expressed in this(More)