Fernando Fernandez-Llimos

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OBJECTIVE To describe the evolution of antidepressant use in primary care in the Valencian region (Spain) from 2000 to 2004 and to analyze the effects of reference-based price and generic drugs introduction on drug utilization and cost saving. METHODS Retrospective observational study in primary care using sales data collected from antidepressant group(More)
OBJECTIVE Our aim was to estimate the prevalence of medicine-related problems, understood as negative clinical outcomes, that result in hospital emergency department (ED) visits and to establish relationships among risk factors and the appearance of pharmacotherapy negative outcomes. METHODS Methods A stratified two-stage probabilistic sampling approach(More)
BACKGROUND Implementation science and knowledge translation have developed across multiple disciplines with the common aim of bringing innovations to practice. Numerous implementation frameworks, models, and theories have been developed to target a diverse array of innovations. As such, it is plausible that not all frameworks include the full range of(More)
BACKGROUND cognitive pharmaceutical services (CPSs) encompass a variety of pharmacists' interventions to optimise pharmacotherapy. The clinical effectiveness of CPSs for aged patients remains controversial. OBJECTIVE to analyse and describe the evidence of the clinical effectiveness of CPSs in aged patients by means of performing a systematic review of(More)
Beyond the commonly mentioned limitations of the Journal Impact Factor, we discuss the obsolete principle of selecting journals to create a fake-representative sample of 'journals that matter' and the opacity around the calculation and listing of Impact Factors. We use the example of Pharmacy Practice: in 2015 for illustration. We hypothesize that a(More)
Information about dosing adjustments in patients with chronic kidney disease is important to avoid toxicity for several medicines. The aim of our study was to assess the clinical relevance of the instructions for dose adjustment in patients with renal impairment provided in the Summaries of Product Characteristics (SmPCs) approved by the European Medicines(More)
1 Since 1990, the question 'What is pharmaceutical care' was usually answered with Hepler and Strand's definition: ''Pharmaceutical care is the responsible provision of drug therapy for the purpose of achieving definite outcomes that improve a patient's quality of life''. 1 Nonetheless, already since 1990 some debate existed about different elements in this(More)
BACKGROUND Implementation of pharmacy services in dialysis centers seems to be limited and requires acceptance from nephrologists. The aim of this study was to explore the opinions of Australian and Portuguese nephrologists toward a potential future provision of clinical pharmacy services in outpatient dialysis centers. METHODS A qualitative study using(More)