Fernando Fernández-Fuertes

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Thrombotic Thrombocytopenic Purpura (TTP) and Antiphospholipid Syndrome (APS) are two well-differentiated processes. TTP is an infrequent disease characterized by microangiopathic haemolytic anaemia, thrombocytopenia, neurological manifestations and renal failure. The occlusion of the microvessels by microthrombi, mainly composed of platelets, constitutes(More)
Eltrombopag is effective and safe in immune thrombocytopenia (ITP). Some patients may sustain their platelet response when treatment is withdrawn but the frequency of this phenomenon is unknown. We retrospectively evaluated 260 adult primary ITP patients (165 women and 95 men; median age, 62 years) treated with eltrombopag after a median time from diagnosis(More)
An IgM 11-oxycorticosteroid-dependent antibody was identified in the serum of a patient with bladder malignancy, which at 4-37 degrees C reacted with all the 11-oxycorticosteroids tested but not with desoxycorticosterone, testosterone, nortestosterone and progesterone. The resulting drug-antidrug antibody complex combines nonspecifically with red blood(More)
PURPOSE To analyse the survival from diagnosis to blastic crisis, as well as the causes of death and the significance of different features in patients diagnosed of chronic myelogenous leukaemia (CML). MATERIAL AND METHODS The series includes 98 patients who died of CML in Asturias Central Hospital and other nearby hospital between 1970 and 1990. The CML(More)
The thrombopoietin receptor agonists (THPO-RAs), romiplostim and eltrombopag, are effective and safe in immune thrombocytopenia (ITP). However, the value of their sequential use when no response is achieved or when adverse events occur with one THPO-RA has not been clearly established. Here we retrospectively evaluated 51 primary ITP adult patients treated(More)
OBJECTIVE To describe the reasons for and result of thrombopoietin receptor agonists (TPO-RA) switching in adult immune thrombocytopenia (ITP) patients of 4 Spanish centres. METHODS We retrospectively analysed all patients who received sequential treatment with both TPO-RA between 2010 and 2015 recording clinical and biological parameters. RESULTS(More)
1. Wilson ML, Weinstein MP, Reimer LG, Mirett S, Relier LB: Controlled comparison of the BacT/Alert and Bactec 660/730 nonradiometric blood culture systems. Journal of Clinical Microbiology 1992, 30: 323-329. 2. Thorpe TC, Wilson ML, Turner JE, Diguiseppi JL, Willert M, Mirrett S, Relier LB: BacT/Alert: an automated colorimetric microbial detection system.(More)
Eltrombopag is safe and effective in primary chronic ITP. However, lack of clinical trials avoids a clear demonstration of its utility in newly diagnosed and persistent ITP. Our aim here is to report Spanish results for this type of patients. We retrospectively evaluated 220 adult primary ITP patients. According to standard definition, patients were(More)
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