Fernando F. Costa

Irene Lorand-Metze2
Fabiola Traina2
2Irene Lorand-Metze
2Fabiola Traina
1Sara T. Saad
1João A. Machado-Neto
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BACKGROUND Acute promyelocytic leukemia is a cytogenetically well defined entity. Nevertheless, some features observed at diagnosis are related to a worse outcome of the patients. METHODS In a prospective study, we analyzed peripheral (PB) leukocyte count, immunophenotype, methylation status of CDKN2B, CDKN2A and TP73; FLT3 and NPM1 mutations besides(More)
BACKGROUND Myelodysplastic syndromes (MDS) are a group of clonal hematological disorders characterized by ineffective hematopoiesis with morphological evidence of marrow cell dysplasia resulting in peripheral blood cytopenia. Microarray technology has permitted a refined high-throughput mapping of the transcriptional activity in the human genome. Non-coding(More)
  • Daniela P. Leonardo, Dulcinéia M. Albuquerque, Carolina Lanaro, Letícia C. Baptista, José G. Cecatti, Fernanda G. Surita +6 others
  • 2015
BACKGROUND Preeclampsia is one of the leading causes of maternal and neonatal morbidity and mortality in the world, but its appearance is still unpredictable and its pathophysiology has not been entirely elucidated. Genetic studies have associated single nucleotide polymorphisms in genes encoding nitric oxide synthase and matrix metalloproteases with(More)
Cerebrovascular lesions are frequently observed in patients with sickle-cell disease (SCD) and these structural lesions are preceded by insidious perfusion deficits. Our aim was to investigate the presence of brain perfusion deficits in neurologically asymptomatic SCD patients, especially affecting microvessels. For this study, 42 SCD patients [33(More)
  • João Paulo L Franco Cairo, Flávia C Leonardo, Thabata M Alvarez, Daniela A Ribeiro, Fernanda Büchli, Ana M Costa-Leonardo +5 others
  • 2011
BACKGROUND Lignocellulosic materials have been moved towards the forefront of the biofuel industry as a sustainable resource. However, saccharification and the production of bioproducts derived from plant cell wall biomass are complex and lengthy processes. The understanding of termite gut biology and feeding strategies may improve the current state of(More)
Proteins containing an Rho GTPase-activating protein (RhoGAP) domain work as molecular switches involved in the regulation of diverse cellular functions. The ability of these GTPases to regulate a wide number of cellular processes conies from their interactions with multiple effectors and inhibitors, including the RhoGAP family, which stimulates their(More)
  • Paula de Melo Campos, João A. Machado-Neto, Christopher A. Eide, Samantha L. Savage, Renata Scopim-Ribeiro, Adriana da Silva Souza Duarte +7 others
  • 2016
The recurrent V617F mutation in JAK2 (JAK2V617F) has emerged as the primary contributor to the pathogenesis of myeloproliferative neoplasms (MPN). However, the lack of complete response in most patients treated with the JAK1/2 inhibitor, ruxolitinib, indicates the need for identifying pathways that cooperate with JAK2. Activated JAK2 was found to be(More)
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