Fernando Coutinho

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BACKGROUND AND OBJECTIVES The mechanism of action of alpha2-adrenergic analgesia has been explored for more than one hundred years. The increased duration of the sensitive and motor blockades caused by clonidine is dose-dependent and has antinociceptive properties. The objective of this study was to evaluate whether the addition of 15 to 30 microg of(More)
This paper presents a novel control architecture for controlling a moving remote center of motion in addition to the end-effector motion during robotic surgery. In minimally invasive surgery, it is common to require that the point at which the robot enters the body, called the incision point or the trocar, does not allow for any lateral motion. It is(More)
We designed a phase I trial to assess the feasibility of the combination of topotecan, Ara-C, cisplatin and solumedrol (TOPOSHAP) in patients with relapsed or primary refractory lymphomas. We included 9 patients with measurable non-Hodgkin's (n = 8) and Hodgkin's (n = 1) lymphomas. Level 1 consisted of topotecan 1.0 mg/m(2)/day, i.v., given on days 1-3,(More)
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