Fernando Bellot

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Cultured NIH 3T3 cells devoid of endogenous EGF receptors were transfected with cDNA constructs encoding either the human EGF receptor or an EGF receptor mutant in which Lys721, a key residue in the ATP binding site, was replaced with an alanine residue. The mutant receptor was properly processed, and it displayed both high- and low-affinity surface binding(More)
Objective Quantitative analysis of MR images is becoming increasingly important in assessing the progression of multiple sclerosis (MS) and in monitoring the effect of a drug therapy. In clinical trials, manual analysis of the MR images by human experts is prohibitively time-consuming because of the large amounts of data typically involved. The inter-and(More)
We have tested the effects of an mAb directed against the protein core of the extracellular domain of the human EGF receptor (mAb108), on the binding of EGF, and on the early responses of cells to EGF presentation. We used NIH 3T3 cells devoid of murine EGF receptor, transfected with a cDNA encoding the full-length human EGF receptor gene, and fully(More)
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