Fernanda Andrade

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To assess the potential of polymeric nanoparticles (NPs) to affect the genital distribution and local and systemic pharmacokinetics (PK) of the anti-HIV microbicide drug candidate dapivirine after vaginal delivery. Dapivirine-loaded, poly(ethylene oxide)-coated poly(epsilon-caprolactone) (PEO-PCL) NPs were prepared by a nanoprecipitation method. Genital(More)
In this paper we present our experience in using Virtual Reality Technologies to accurately reconstruct and further explore ancient and historic city buildings. Virtual reality techniques provide a powerful set of tools to explore and access the history of a city. In order to explore, visualize and hear such history, we divided the process in three phases:(More)
AIMS C-type natriuretic peptide (CNP) and nitric oxide (NO) are endothelium-derived factors that play important roles in the regulation of vascular tone and arterial blood pressure. We hypothesized that NO produced by the endothelial NO-synthase (NOS-3) contributes to the relaxation induced by CNP in isolated rat aorta via activation of endothelial NPR-C(More)
— This work presents our experience in using Virtual Reality techniques to digitally reconstruct the downtown of São Paulo city in the year of 1911. Particularly, the reconstruction of old downtown São Paulo could bring relevant information regarding its culture, history and economy. In order to achieve an accurate 3D representation, the process was divided(More)
The freezing step in lyophilization is the most determinant for the quality of biopharmaceutics. Using insulin as model of therapeutic protein, our aim was to evaluate the freezing effect in the stability and bioactivity of insulin-loaded PLGA nanoparticles. The performance of trehalose, sucrose and sorbitol as cryoprotectants was evaluated. Cryoprotectants(More)
This work aimed to design, develop, and characterize a lipid nanocarrier system for the selective delivery of rifabutin (RFB) to alveolar macrophages. Lipid nanoparticles, specifically nanostructured lipid carriers (NLC), were synthetized by the high-shear homogenization and ultrasonication techniques. These nanoparticles were designed to exhibit both(More)
Following sinoaortic denervation (SAD) rats present intense arterial pressure lability without sustained hypertension. This study aimed to verify the effects of heptanol (a putative gap-junction blocker) and tetraethylammonium (TEA, a putative gap-junction activator) on rhythmic contractions (RCs) and vascular reactivity in the aortas isolated from SAD and(More)
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