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1. The role of synaptic activation of NMDA (N-methyl-D-aspartate) receptor-mediated conductances on CA1 hippocampal pyramidal cells in short-term excitability changes was studied with the use of a computational model. Model parameters were based on experimental recordings from dendrites and somata and previous hippocampal simulations. Representation of CA1… (More)
A modeling procedure is proposed which introduces the cable equivalent of dendritic spines into the Rall model of spiny interneurons in the spinal cord. At this point combined morphological and physiological works have given some insight into the possible role of a single spine and the function of a single spine has been studied by theoretical computations… (More)
1. Experimental studies employing whole cell patch recordings from freshly isolated olfactory sensory neurons of the salamander (Ambystoma tigrinum) yield much higher estimates of specific membrane resistance (Rm) than studies using conventional intracellular recordings from in situ neurons. Because Rm is critical for understanding information transfer in… (More)
Typical seizure activity can be induced by applying 3-aminopyridine to the surface of the cat cortex. The well known characteristics of epileptiform discharges were readily observed by simultaneous recording from both the surface and deeper layers.
An analytical, recursive method has been developed to demonstrate the anisotropic electrotonic geometry of nerve cells containing varicose or spiny dendrites. The procedure has been based on the distribution of the core geometry of dendrites into modules which consist of module elements where the physical length is much shorter than the actual space… (More)
Some effects of the convulsant drug pentylenetetrazol (PTZ) on molluscan neurons were simulated. The calculations were based on the voltage clamp results of Connor and Stevens as well as Williamson and Crill. The normal repetitive state and the PTZ-controlled state were compared and threshold phenomena shown by prolonged depolarizations were studied by… (More)